Evidence map›Paper›PMID 42808065›Full record

ArticleNature reviews. Methods primers2026

Matrix-Assisted Laser Desorption/Ionization Imaging Mass Spectrometry.

Jeffrey M Spraggins, Amanda Hummon, Shane R Ellis, Lingjun Li, Boone M Prentice, Martina Marchetti-Deschmann, Raf Van de Plas, Richard M Caprioli

Abstract read
In one paragraph

Article in Nature reviews. Methods primers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jeffrey M SpragginsMass Spectrometry Research Center, Vanderbilt University, Nashville, TN 37232, USA.
Amanda HummonDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.
Shane R EllisMolecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, Australia, 2522.
Lingjun LiSchool of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705, USA.
Boone M PrenticeDepartment of Chemistry, University of Florida, Gainesville, Florida USA 32611.
Martina Marchetti-DeschmannInstitute of Chemical Technologies and Analytics, Vienna University of Technology, 1060 Vienna, Austria.
Raf Van de PlasMass Spectrometry Research Center, Vanderbilt University, Nashville, TN 37232, USA.
Richard M CaprioliMass Spectrometry Research Center, Vanderbilt University, Nashville, TN 37232, USA.

Funding

Vanderbilt University Biomolecular Multimodal Imaging Center for 3-Dimensional Mapping of the Human KidneyU54DK134302 · NIDDK · VANDERBILT UNIVERSITY · PI CAPRIOLI, RICHARD M, SPRAGGINS, JEFFREY M · 2022 to 2025
$7.1M
Mass Spectrometric Studies of Neuropeptides in FeedingR01DK071801 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI LINGJUN LI · 2006 to 2026
$6.7M
Vanderbilt University Biomolecular Multimodal Imaging Center for 3-Dimensional Tissue MappingU54DK120058 · NIDDK · VANDERBILT UNIVERSITY · PI HARRIS, RAYMOND C. · 2018 to 2021
$5.7M
Pancreas Organ Specific ProjectU54EY032442 · NEI · VANDERBILT UNIVERSITY · PI CAPRIOLI, RICHARD M · 2020 to 2024
$5.7M
Molecular mapping of microbial communities at the host-pathogen interface by multi-modal 3-dimensional imaging mass spectrometryR01AI138581 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Eric P Skaar, Jeffrey M Spraggins · 2018 to 2026
$5.2M
A Multimodal 3D Atlas of Colorectal Cancer Across Ages of OnsetU01CA294527 · NCI · VANDERBILT UNIVERSITY · PI LAU, KEN S, SPRAGGINS, JEFFREY M · 2024 to 2025
$5.2M
Defining the impact of host factors on the molecular architecture and bacterial physiology of Staphylococcus aureus abscessesR01AI145992 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CASSAT, JAMES E, SKAAR, ERIC P · 2020 to 2024
$3.8M
Creating a region- specific biomolecular atlas of the brain of Alzheimer’s diseaseR01AG078794 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI LINGJUN LI, Luigi Puglielli · 2022 to 2026
$3.7M
Elucidating Molecular Drivers of Aging and Alzheimer's Disease via Multimodal Imaging Mass SpectrometryR01AG078803 · NIA · VANDERBILT UNIVERSITY · PI Rena A. S. Robinson, Matthew Schrag · 2022 to 2026
$3.5M
Multimodal Imaging Mass Spectrometry and Spatial Omics for the Human KidneyU01DK133766 · NIDDK · VANDERBILT UNIVERSITY · PI Jeffrey M Spraggins · 2022 to 2026
$3.4M
DiLeu-enabled multiplexed quantitation for biomarker discovery and validation in Alzheimer’s diseaseR01AG052324 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI LINGJUN LI · 2023 to 2026
$2.3M
Imaging mass spectrometry at isomeric chemical resolution using gas phase ion/ion reactionsR01GM138660 · NIGMS · UNIVERSITY OF FLORIDA · PI PRENTICE, BOONE M. · 2020 to 2024
$1.6M
NCI NIH HHS U01 CA294527NEI NIH HHS U54 EY032442NIAID NIH HHS R01 AI138581NIAID NIH HHS R01 AI145992NIA NIH HHS R01 AG052324NIA NIH HHS R01 AG078794NIA NIH HHS R01 AG078803NIDDK NIH HHS R01 DK071801NIDDK NIH HHS U01 DK133766NIDDK NIH HHS U54 DK120058NIDDK NIH HHS U54 DK134302NIGMS NIH HHS R01 GM138660NIGMS NIH HHS R35 GM158423
6 · The paper itself

Abstract

Matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) is a powerful molecular imaging technology that is capable of imaging a wide range of molecular classes at cellular resolution. This Primer includes an overview of basic imaging mass spectrometry concepts, instrumentation, processing approaches, and advanced applications. We also address key challenges and considerations with an eye on how to optimize instrumentation and methods to overcome issues with spatial resolution, sensitivity, and specificity.

Identifiers

PMID42808065
PMCPMC13618732

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.