ReviewCureus2026
Regenerative Endodontic Therapies for Immature Permanent Teeth With Pulp Necrosis: A Review of Biological Foundations, Clinical Outcomes, and Future Frontiers.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regenerative endodontics is a very promising biological alternative to root canal treatments because it primarily aims to restore the living pulp-dentin complex instead of just disinfecting and sealing the canal. Current evidence in the field points toward support for symptom relief, periapical healing, continued root development, and apical closure, especially in immature and necrotic teeth. Its core strategies include revascularization, biomaterials, and cell-free methods (exosomes and secretomes). Future directions will most likely have to depend on the improvement of biomaterials, more precise and personalized treatment planning, broader access to stem cells, and stronger translation of research. However, the field's progress continues to be hindered by barriers such as protocol variability, technique sensitivity, infection control, cost, and limited long-term evidence. As a result, regenerative endodontic therapy should be understood as clinically promising but not yet fully standardized or completely reliable.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.