ArticleResearch in autism2025
Behavioral and neural interrelationships of sensory difficulties, intolerance of uncertainty, and anxiety in autistic children.
Article in Research in autism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Purpose: Autistic children often experience higher levels of sensory difficulties and anxiety, compared to their non-autistic counterparts. Available evidence suggests that intolerance of uncertainty (IU) mediates the relationship between these factors. We aimed to further the examination of the interrelationship between these phenomena, as well as their underlying neural mechanisms, in children. Methods: 30 autistic children (ages 6-11 years) and 26 age-matched neurotypical (NT) peers participated in resting-state fMRI, as well as various behavioral assessments of sensory processing, anxiety, and IU. Results: Between-groups comparisons of behavioral scores showed higher levels of sensory processing differences, anxiety, and IU in autistic children. Mediation analysis also revealed that IU was a significant mediator between sensory difficulties and anxiety in this group. Network connectivity findings showed that connectivity between sensory cortices and cerebellar, higher order sensory, and limbic regions (esp. amygdala) were significantly correlated with sensory processing, anxiety, and IU. Conclusion: We report novel behavioral and neurophysiologic findings concerning important interrelationships in autism. Our findings may be related to predictive coding accounts of autism. Our results have the potential to inform future clinical practice, in that addressing sensory and IU difficulties has the potential to lead to improvements in anxiety in autistic children.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.