ArticleRSC advances2026
Design, synthesis and network pharmacology-integrated evaluation of benzenesulfonamides as potential Dickkopf-1 (Dkk-1)-targeting anticancer candidates.
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
9 authors.
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Abstract
Sulfanilamide-based drugs are known to exhibit immense anti-cancer activities, and thus, we sought to design and formulate sulfanilamide derivatives in order to study their potential against carbonic anhydrase II, pancreatic elastase, Dickkopf-1 (Dkk1) and LRP6 proteins, which are potential anti-cancer targets for various cancers. Out of all the synthesized derivatives, compound 4d exhibited significant inhibitory potential against CA-II, with an IC
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