Evidence map›Paper›PMID 42807947›Full record

ArticleInternational journal of biological sciences2026

ZIP1-dependent lymphatic adaptations facilitate lymph node metastasis of pancreatic cancer.

Ruoyang Chen, Kaili Zhang, Jiajia Wan, Yuanyuan Yang, Linlin Wang, Xiangjing Miao, Qingqing Fang, Yu Hu, Xixi Duan, Xiaohan Lou and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ruoyang ChenMedical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Kaili ZhangMedical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Jiajia WanMedical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Yuanyuan YangMedical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Linlin WangMedical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Xiangjing MiaoMedical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Qingqing FangMedical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Yu HuMedical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Xixi DuanMedical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Xiaohan LouMedical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Xiaohan YaoMedical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Anqi LiMedical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Linyu ZhuMedical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Zhihai QinMedical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Chen NiMedical Research Center, Henan China-Germany International Joint Laboratory of Tumor Immune Microenvironment and Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor disseminates through lymphatic vessels to form lymph node (LN) metastasis, which requires lymphatic adaptations. However, it remains largely unknown how lymphatic vessels adapt to the stimuli causing LN metastasis of pancreatic cancer. Zinc dyshomeostasis has been observed in various tumors, including pancreatic cancer. We hypothesize that lymphatic vessels actively adapt to zinc imbalance, and examine lymphatic functions and LN metastasis of transplanted pancreatic cancer in zinc transporter ZIP1 deficient mice. The results show that ZIP1 is required for lymphatic glycolysis and junctional adaptations that facilitate LN metastasis of pancreatic cancer. In

Indexed as

Cation Transport ProteinsLymphatic MetastasisLymphatic VesselsPancreatic NeoplasmsAnimalsClaudin-5GlycolysisHumansLymph NodesMiceMice, KnockoutZincCation Transport ProteinsClaudin-5ZincClaudin-5glycolysislymphatic endothelial celllymph node metastasispancreatic cancerZIP1

Identifiers

PMID42807947
PMCPMC13618232

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.