Evidence map›Paper›PMID 42807941›Full record

ArticleJournal of breast cancer research2026

Uncovering genetic variations in HTR2A and miRNAs drivers of breast cancer risk in African American women.

Nicole Retland, Karl M Thompson, Joseph I Aubee, Victor Apprey, Somiranjan Ghosh, Robert Copeland, Yasmine Kanaan, Yayin Fang, Ali Ramadan, Hassan Brim and 1 more

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Article in Journal of breast cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Nicole RetlandFielding Graduate University, Center for the Advancement of STEM Leadership, Santa Barbara, CA, USA.
Karl M ThompsonHoward University, Department of Microbiology, Washington, DC, USA.
Joseph I AubeeHoward University, Department of Microbiology, Washington, DC, USA.
Victor AppreyThe National Human Genome Center, Howard University, Washington, DC, USA.
Somiranjan GhoshHoward University, College of Arts and Sciences, Washington, DC, USA.
Robert CopelandHoward University, Department of Pharmacology, Washington, DC, USA.
Yasmine KanaanHoward University, Department of Microbiology, Washington, DC, USA.
Yayin FangHoward University, Department of Biochemistry, Washington, DC, USA.
Ali RamadanHoward University, Department of Pathology, Washington, DC, USA.
Hassan BrimHoward University, Department of Pathology, Washington, DC, USA.
Muneer M AbbasHoward University, Department of Microbiology, Washington, DC, USA.

Funding

Sleep Disorders in Adults with Sickle Cell Disease: Frequency, Associations with Cardiovascular and Pain Indicators, and Responses to TreatmentU54MD007597 · NIMHD · HOWARD UNIVERSITY · PI BYRON D. FORD · 2019 to 2026
$37.7M
NIMHD NIH HHS U54 MD007597
6 · The paper itself

Abstract

Background/Objectives: Triple-negative breast cancer (TNBC) disproportionately affects African American (AA) women, yet the molecular mechanisms remain poorly understood. Emerging evidence suggests that microRNAs (miRNAs) may play a critical role in cancer progression. This study investigated the association of HTR2A genetic variants and miRNA dysregulation in AA women with breast cancer. Methods: A total of 417 AA women (192 with breast cancer, 225 controls) were genotyped for selected HTR2A SNPs. Functional predictions and molecular modeling assessed structural impact. TNBC cell lines were treated with an HTR2A agonist, and miRNA expression was profiled using the NanoString, and bioinformatic tools were applied to identify miRNA targets and associated oncogenic pathways. Results: Three SNPs (rs6304, rs6311, and rs1745837) were significantly associated with breast cancer risk (e.g., rs6311 dominant model: OR = 11.98, 95% CI: 6.63-21.66, p < 0.0001). The rs6304 demonstrated predicted protein destabilization. Six oncogenic miRNAs (including miR-92a-3p and miR-377-3p) were significantly upregulated (p < 0.05) and involved in PI3K/AKT, JAK/STAT, and IL-6 pathways. Conclusions: HTR2A genetic variation, miRNA dysregulation, and increased breast cancer risk in AA women. These findings suggest that HTR2A variants and miRNA profiles may serve as potential biomarkers for risk stratification and targeted therapeutic approaches in TNBC. Simple Summary: African American women face a higher risk of developing a particularly aggressive type of breast cancer called TNBC. This study explores how changes in a specific serotonin receptor gene, known as HTR2A, might contribute to this risk. By analyzing the DNA of AA women and conducting lab experiments, the researchers identified genetic variations that are more common in women with breast cancer. They also discovered that these genetic changes may affect the way small molecules called microRNAs control cell growth. Understanding these links may help scientists find better ways to detect and treat breast cancer in AA women, paving the way for more personalized and effective medical care.

Indexed as

African American womenBreast cancer disparitiesGene regulationHTR2A genemicroRNAPrecision medicineSingle nucleotide polymorphismsTriple-Negative breast cancer

Identifiers

PMID42807941
PMCPMC13618301

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