Evidence map›Paper›PMID 42807934›Full record

ArticleInternational journal of biological sciences2026

Human-Mouse Chimerism for Organogenesis Without Neural or Germline Contributions.

Sen Ye, Kailibinuer Kadier, Ye Yi, Guihui Qin, Borong Huang, Siyi Fu, Cantas Alev, Ren-He Xu

Abstract read
In one paragraph

Article in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sen YeCenter of Reproduction, Development & Aging, Institute of Translational Medicine, Faculty of Medicine, and Ministry of Education Frontiers Science Center on Precision Oncology, University of Macau, Taipa, Macau SAR 999078, China.
Kailibinuer KadierCenter of Reproduction, Development & Aging, Institute of Translational Medicine, Faculty of Medicine, and Ministry of Education Frontiers Science Center on Precision Oncology, University of Macau, Taipa, Macau SAR 999078, China.
Ye YiCenter of Reproduction, Development & Aging, Institute of Translational Medicine, Faculty of Medicine, and Ministry of Education Frontiers Science Center on Precision Oncology, University of Macau, Taipa, Macau SAR 999078, China.
Guihui QinCenter of Reproduction, Development & Aging, Institute of Translational Medicine, Faculty of Medicine, and Ministry of Education Frontiers Science Center on Precision Oncology, University of Macau, Taipa, Macau SAR 999078, China.
Borong HuangCenter of Reproduction, Development & Aging, Institute of Translational Medicine, Faculty of Medicine, and Ministry of Education Frontiers Science Center on Precision Oncology, University of Macau, Taipa, Macau SAR 999078, China.
Siyi FuCenter of Reproduction, Development & Aging, Institute of Translational Medicine, Faculty of Medicine, and Ministry of Education Frontiers Science Center on Precision Oncology, University of Macau, Taipa, Macau SAR 999078, China.
Cantas AlevInstitute for the Advanced Study of Human Biology (ASHBi), University of Kyoto, Kyoto, Japan.
Ren-He XuCenter of Reproduction, Development & Aging, Institute of Translational Medicine, Faculty of Medicine, and Ministry of Education Frontiers Science Center on Precision Oncology, University of Macau, Taipa, Macau SAR 999078, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human pluripotent cells, including embryonic stem cells (ESCs), have been used for interspecies blastocyst complementation, with the potential to generate human organs in animals for clinical applications. However, ethical concerns exist as human cells may contribute to the germline and central nervous system (CNS) in chimeric animals. To prevent such concerns, here we generated

Indexed as

ChimerismOrganogenesisAnimalsChimeraEmbryonic Stem CellsFemaleHumansMicePAX6 Transcription FactorPositive Regulatory Domain I-Binding Factor 1PAX6 Transcription FactorPositive Regulatory Domain I-Binding Factor 1chimeraethicsgermline cellsneural cellsorganogenesis

Identifiers

PMID42807934
PMCPMC13618233

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.