Evidence map›Paper›PMID 42807888›Full record

ArticleJournal of oral microbiology2026

Effects of Berberine chloride hydrate on cariogenic multispecies streptococcal biofilm.

Yang Zhou, Guxin Cui, Fang Huang, Huancai Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of oral microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yang ZhouHospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou, China.ORCID https://orcid.org/0009-0004-6413-5382
Guxin CuiHospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou, China.ORCID https://orcid.org/0009-0009-3412-9981
Fang HuangHospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou, China.
Huancai LinHospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou, China.ORCID https://orcid.org/0000-0001-7923-9927

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Dental caries, a bacterial infectious disease related to biofilm, occurs due to an increase in the proportion of cariogenic bacteria over that of commensal bacteria. This study aimed to create an in vitro biofilm model consisting of Materials and methods: The biofilm formation and cariogenic characteristics of multispecies streptococci biofilms were observed. The microbial composition of multispecies biofilms was quantified using fluorescent in situ hybridization (FISH). Besides, transcriptome analysis was performed to determine the differential expression levels of genes in each strain in multispecies biofilms with or without BH. The demineralization activity of biofilms treated with BH was analyzed using micro-CT. Results: BH had the highest efficacy against Conclusion: BH revealed great potential for the management of cariogenic biofilm, indicating its possible application in dental caries therapy.

Indexed as

Berberine chloride hydratebiofilmsStreptococcus gordoniiStreptococcus mutansStreptococcus sanguinis

Identifiers

PMID42807888
PMCPMC13618191

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.