Evidence map›Paper›PMID 42807861›Full record

ArticleInternational journal of biological sciences2026

Functional Genomic Screening Identifies lncRNA CNPY2-AS1 as a Regulator of Redox Metabolism and Antiviral Immunity.

Carolina Khoury, Tahleel Ali-Nasser, Yuval Ben Eliahu, Haya Dahamshy Silawi, Liran Ben Yaakov, Simon Rousseau, Yvan Devaux, Nisrine Lahoud-Jeries, Assaf C Bester

Abstract read
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Article in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Carolina KhouryDepartment of Biology, Technion-Israel Institute of Technology, 3200003, Haifa, Israel.
Tahleel Ali-NasserDepartment of Biology, Technion-Israel Institute of Technology, 3200003, Haifa, Israel.
Yuval Ben EliahuDepartment of Biology, Technion-Israel Institute of Technology, 3200003, Haifa, Israel.
Haya Dahamshy SilawiDepartment of Biology, Technion-Israel Institute of Technology, 3200003, Haifa, Israel.
Liran Ben YaakovDepartment of Biology, Technion-Israel Institute of Technology, 3200003, Haifa, Israel.
Simon RousseauThe Meakins-Christie Laboratories at the Research Institute of the McGill University Health Center, & Department of Medicine, Faculty of Medicine, McGill University, Montréal, QC, Canada.
Yvan DevauxCardiovascular Research Unit, Department of Precision Health, Luxembourg Institute of Health, 1A-B rue Edison, L-1445 Strassen, Luxembourg.
Nisrine Lahoud-JeriesDepartment of Biology, Technion-Israel Institute of Technology, 3200003, Haifa, Israel.
Assaf C BesterDepartment of Biology, Technion-Israel Institute of Technology, 3200003, Haifa, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human genome encodes thousands of long non-coding RNAs (lncRNAs) that regulate innate immunity and viral life cycles, yet their roles in viral entry remain understudied. Here, we conducted a genome-wide CRISPR interference screen to identify lncRNAs that regulate SARS-CoV-2 entry. We identified two lncRNAs that modulate angiotensin-converting enzyme 2 (ACE2) dependent viral entry through distinct mechanisms. Our findings suggest that the RP11-314A20.5 locus acts as a

Indexed as

COVID-19Immunity, InnateRNA, Long NoncodingSARS-CoV-2Angiotensin-Converting Enzyme 2HEK293 CellsHumansOxidation-ReductionVirus InternalizationACE2 protein, humanAngiotensin-Converting Enzyme 2RNA, Long Noncodinginnate immunityinterferon-stimulated genes (ISGs)long non-coding RNA (lncRNA)redox homeostasisSARS-CoV-2

Identifiers

PMID42807861
PMCPMC13618004

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.