ReviewERJ open research2026
Effect of ventilatory support pressure during exercise on endurance time in patients with COPD: a systematic review.
Review in ERJ open research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rationale: Noninvasive ventilation during exercise has been proposed to improve exercise tolerance in patients with COPD. However, the influence of fixed pressure support intensity on endurance performance and exercise-related physiological responses remains insufficiently clarified. Materials and methods: A systematic review and meta-analysis were conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PROSPERO CRD420251018584). Randomised controlled and crossover trials evaluating noninvasive ventilation delivered in fixed pressure support mode during exercise were included. Random-effects models were applied to pool standardised mean differences (SMD). Mixed-effects meta-regression analyses assessed the association between pressure support level and outcomes. The primary outcome was endurance time. Secondary outcomes included dyspnoea (modified Borg scale) and hypercapnia. Results: A total of 15 studies (285 participants) were included. Noninvasive ventilation significantly improved endurance time compared with control conditions (SMD 0.47, 95% CI 0.20 to 0.73). Pressure support intensity was not significantly associated with endurance time (β=0.0345 per cmH Conclusion: Noninvasive ventilation during exercise improves endurance and dyspnoea in COPD. Pressure support intensity influences ventilatory unloading, but endurance performance appears multifactorial. Further standardised studies are needed to optimise pressure titration during exercise.
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Registered trials
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