Evidence map›Paper›PMID 42807821›Full record

ArticleERJ open research2026

Reduced vascular function, ventilatory efficiency and exercise capacity in young adult electronic cigarette users.

Azmy Faisal, Agata Giles, Sarah Jones, Christopher I Morse, Hans Degens, Caroline J Jolley, Steven K Rogers, Rashid Ahmed, Amany F Elbehairy, Rehan T Junejo

Abstract read
In one paragraph

Article in ERJ open research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Azmy FaisalDepartment of Sport and Exercise Sciences, Manchester Metropolitan Institute of Sport, Manchester Metropolitan University, Manchester, UK.ORCID https://orcid.org/0000-0001-5019-7292
Agata GilesDepartment of Sport and Exercise Sciences, Manchester Metropolitan Institute of Sport, Manchester Metropolitan University, Manchester, UK.
Sarah JonesDepartment of Life Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, UK.
Christopher I MorseDepartment of Sport and Exercise Sciences, Manchester Metropolitan Institute of Sport, Manchester Metropolitan University, Manchester, UK.
Hans DegensDepartment of Life Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, UK.
Caroline J JolleyCentre for Human & Applied Physiological Sciences, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.ORCID https://orcid.org/0000-0003-3538-2451
Steven K RogersManchester Academic Vascular Research and Innovation Centre, Manchester Vascular Centre, Manchester University NHS Foundation Trust, Manchester, UK.
Rashid AhmedCollege for Community Health, Montclair State University, Montclair, NJ, USA.
Amany F ElbehairyDivision of Respirology and Sleep Medicine, Department of Medicine, Queen's University and Kingston Health Sciences Centre, Kingston, ON, Canada.ORCID https://orcid.org/0000-0001-5180-519X
Rehan T JunejoDepartment of Life Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, UK.ORCID https://orcid.org/0000-0002-0670-8339

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Acute electronic cigarette (E-cigarette) use has shown adverse cardiorespiratory impacts similar to conventional cigarette (C-cigarette) smoking; however, its early effects remain unclear. We aimed to examine the early effects of E-cigarette use on systemic vascular function, cardiorespiratory responses to exercise and exertional symptoms in young adults. Methods: 75 healthy active young adults (18-30 years), divided into three age- and sex-matched groups (E-cigarette users, C-cigarette smokers and never-smoker controls; n=25 each, E-cigarette use or smoking duration ≥18 months), underwent an incremental cycle exercise test with standard metabolic, cardiorespiratory, blood lactate and sensory measurements. Brachial artery flow-mediated dilatation (FMD) was assessed using Doppler ultrasound. Blood samples were collected to assess vascular inflammatory markers. Results: Cotinine (nicotine metabolite) levels were not different between E-cigarette users and C-cigarette smokers (80.7±33.0 Conclusion: E-cigarette use and C-cigarette smoking were both associated with early detrimental effects on exercise capacity, ventilatory efficiency, systemic vascular function and amplified exertional symptoms.

Identifiers

PMID42807821
PMCPMC13617591

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.