Evidence map›Paper›PMID 42807779›Full record

ArticleBurns & trauma2026

Deciphering the cellular landscape of pathological scars.

Yixin Sun, Sijing Yan, Mengdi Zhang, Wangfei Mo, Catharina Tao, Jingyu Li, Jiuzuo Huang, Nanze Yu, Yi Sun, Xiao Long

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Burns & trauma, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yixin SunCenter for Plastic and Reconstructive Surgery, Department of Plastic and Reconstructive Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, No. 158, Shangtang Road, Gongshu District, Hangzhou, Zhejiang 310014, China.
Sijing YanDepartment of Plastic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 41, Damucang Hutong, Xicheng District, Beijing 100032, China.
Mengdi ZhangDepartment of Plastic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 41, Damucang Hutong, Xicheng District, Beijing 100032, China.
Wangfei MoDepartment of Plastic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 41, Damucang Hutong, Xicheng District, Beijing 100032, China.
Catharina TaoSchool of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0SP, United Kingdom.
Jingyu LiCenter for Plastic and Reconstructive Surgery, Department of Plastic and Reconstructive Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, No. 158, Shangtang Road, Gongshu District, Hangzhou, Zhejiang 310014, China.
Jiuzuo HuangDepartment of Plastic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 41, Damucang Hutong, Xicheng District, Beijing 100032, China.
Nanze YuDepartment of Plastic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 41, Damucang Hutong, Xicheng District, Beijing 100032, China.ORCID https://orcid.org/0009-0009-3675-7199
Yi SunCenter for Plastic and Reconstructive Surgery, Department of Plastic and Reconstructive Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, No. 158, Shangtang Road, Gongshu District, Hangzhou, Zhejiang 310014, China.
Xiao LongDepartment of Plastic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 41, Damucang Hutong, Xicheng District, Beijing 100032, China.ORCID https://orcid.org/0000-0003-0136-2508

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pathological scars (PSs) are characterized by excess dermal collagen deposition and primarily manifest as hypertrophic scars and keloids. The microenvironment of PSs is shaped by a diverse array of cells, collectively forming a profibrotic and proangiogenic niche. Recent advances in high-throughput sequencing have enhanced our understanding of the cellular heterogeneity, transcriptional changes, and intercellular communication within the PS microenvironment. This review comprehensively describes the cellular landscape of PSs, including mesenchymal cells, endothelial cells, epithelial cells, and immune cells. Additionally, we evaluate precision medicine strategies ranging from biomarker-driven diagnostics to targeted biological therapies and innovative drug delivery systems. We aim to provide a mechanistic framework that accelerates the translation of basic experimental research into effective and personalized treatments for pathological scarring.

Indexed as

Cellular landscape, Pathological scarHypertrophic scarKeloidWound healing

Identifiers

PMID42807779
PMCPMC13619338

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.