ArticleFrontiers in pediatrics2026
Association of the inflammation indicators with multiple system involved of immunoglobulin A vasculitis in children.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Immunoglobulin A vasculitis (IgAV) is the most common childhood vasculitis, and involvement of multiple systems (gastrointestinal, joint, renal) may affect prognosis. Reliable biomarkers for predicting multi-system involvement are needed. Objective: To investigate the association between routine inflammation-related laboratory indicators and multi-system involvement in children with IgAV. Methods: A retrospective study included 657 children with IgAV diagnosed according to EULAR/PRINTO/PRES criteria. Patients were categorized into five mutually exclusive subgroups based on clinical phenotypes: skin only ( Results: Multi-system involvement was the most common phenotype (45.2%). Compared with other subgroups, multi-system involvement patients showed significantly higher WBC ( Conclusion: Elevated inflammatory markers including WBC, neutrophils, platelets, NLR, PLR, and D-dimer, as well as decreased albumin, are associated with multi-system involvement in children with IgAV, with the most pronounced differences observed between multi-system and skin-only groups. Onset age >10 years is associated with increased renal involvement risk. These routine laboratory indicators, interpreted in conjunction with age and disease duration, may aid in early risk stratification.
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