ArticleIranian journal of pharmaceutical research : IJPR
Anti-osteoporotic Effect of
Article in Iranian journal of pharmaceutical research : IJPR. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Osteoporosis (OP) is a metabolic bone disorder that predominantly affects postmenopausal women. Objectives: This study aimed to evaluate the anti-osteoporotic activity of Methods: Female Sprague-Dawley (SD) rats were randomly assigned to six experimental groups (n = 6 per group): group I, control; group II, RA alone (75 mg/kg body weight/day); group III, RA + alendronate (5 mg/kg body weight); group IV, RA + SXLE (25 mg/kg body weight); group V, RA + SXLE (50 mg/kg body weight); and group VI, RA + SXLE (100 mg/kg body weight). Bone mineral density (BMD), bone length, bone mineral content, serum estradiol levels, osteocalcin (OCN), alkaline phosphatase (ALP), and tartrate-resistant acid phosphatase (TRAP) activity were measured. The mRNA expression levels of TNF-α, IL-6, TP53 (tumor protein p53), NOX1 (NADPH oxidase 1), NOX2 (NADPH oxidase 2), SOD1 (superoxide dismutase 1), and SOD2 (superoxide dismutase 2) were evaluated by RT-qPCR. Results: SXLE treatment significantly increased body weight, bone mineral content, bone length, relative bone density, serum estradiol, osteocalcin, and BMD in a dose-dependent manner. Conversely, SXLE dose-dependently reduced ALP and TRAP activities and decreased the mRNA expression of TNF-α, IL-6, and TP53. SXLE improved tibial and femoral coefficients and lengths, increased trabecular relative bone density, and enhanced the cortical bone area ratio. The therapeutic effects of SXLE at 100 mg/kg body weight were comparable to those of alendronate (5 mg/kg body weight). Furthermore, SXLE downregulated the expression of NOX1 and NOX2 while upregulating the expression of SOD1 and SOD2. Conclusions: SXLE enhances osteoblastic/osteogenic activity while suppressing osteoclastic activity, indicating significant anti-osteoporotic potential in rats with RA-induced osteoporosis. This is the first report to link SXLE to modulation of the NOX1/NOX2-SOD1/SOD2 oxidative stress pathway in bone, providing a potential molecular mechanism for its bone-protective effects. In addition, SXLE at 100 mg/kg demonstrated therapeutic efficacy comparable to that of alendronate, supporting its potential as a plant-based alternative to bisphosphonates for osteoporosis management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.