ReviewJournal of Cancer2026
Molecular mechanism and potential role of mitophagy in breast cancer.
Review in Journal of Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Breast cancer remains the most commonly diagnosed malignancy among women worldwide and a leading cause of cancer related mortality in this population. Mitochondrial dysfunction is increasingly recognized as a hallmark of breast cancer, contributing to tumor initiation, progression, and therapeutic resistance. Mitophagy, a selective form of autophagy that eliminates damaged or dysfunctional mitochondria, is essential for maintaining cellular and mitochondrial homeostasis. Accumulating evidence indicates that mitophagy plays a context dependent role in breast cancer. Impaired mitophagy permits the accumulation of damaged mitochondria and promotes tumor growth, migration, and invasion, whereas appropriately activated mitophagy removes damaged mitochondria and suppresses tumor progression. This review synthesizes the molecular mechanisms of mitophagy, its crosstalk with ferroptosis, and its context dependent roles in breast cancer development, with the aim of offering therapeutic insights that may inform breast cancer treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.