ArticleCHEST pulmonary2026
Can Quantitative CT Scan Analysis of Pulmonary Parenchymal and Vascular Characteristics Help to Differentiate Among Various Phenotypes of COPD Associated With Pulmonary Hypertension?
Article in CHEST pulmonary, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Quantitative CT imaging has been applied to pulmonary vascular disease, but its role in characterizing phenotypes of COPD associated with pulmonary hypertension (COPD-PH) has not been evaluated systematically. Research Question: Can quantitative CT imaging reliably identify and differentiate major COPD-PH phenotypes? Study Design and Methods: We conducted a retrospective cohort study of patients with COPD-PH at Temple University Hospital from 2010 through 2022. Patients were categorized into 3 phenotypes: pulmonary vascular (pulmonary vascular resistence [PVR] > 5 Wood units [WU]; FEV Results: Ninety patients met inclusion criteria. Mean PVR was 9.5 WU, 7.5 WU, and 2.8 WU in the vascular, mixed, and parenchymal phenotypes, respectively; corresponding mean FEV Interpretation: Our results show that quantitative CT imaging can differentiate COPD-PH phenotypes using vascular and parenchymal markers and may serve as a noninvasive tool to characterize disease heterogeneity.
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