Evidence map›Paper›PMID 42807573›Full record

ReviewFood science & nutrition2026

Converting Equol Nonproducers to Producers: A Systematic Review of Randomized Clinical Trials.

Jiatong Li, Mengyi Li, Saied Aboushanab, Mark Ebeid, Rieko Hatanaka, Miho Iida, Masato Takase, Ian Jacobs, Arnur Gusmanov, Aya Hirata and 9 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Food science & nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Jiatong LiDepartment of Epidemiology, School of Public Health University of Pittsburgh Pittsburgh Pennsylvania USA.ORCID https://orcid.org/0000-0003-3778-5633
Mengyi LiDepartment of Epidemiology, School of Public Health University of Pittsburgh Pittsburgh Pennsylvania USA.ORCID https://orcid.org/0000-0001-6514-1793
Saied AboushanabUral Federal University Yekaterinburg Russia.ORCID https://orcid.org/0000-0002-9716-9229
Mark EbeidComputational and Systems Biology, School of Medicine University of Pittsburgh Pittsburgh Pennsylvania USA.ORCID https://orcid.org/0000-0002-9113-7082
Rieko HatanakaTohoku Medical Megabank Organization Tohoku University Sendai Miyagi Japan.
Miho IidaDepartment of Preventive Medicine and Public Health Keio University School of Medicine Tokyo Japan.ORCID https://orcid.org/0000-0001-5527-7574
Masato TakaseTohoku Medical Megabank Organization Tohoku University Sendai Miyagi Japan.
Ian JacobsDepartment of Epidemiology, School of Public Health University of Pittsburgh Pittsburgh Pennsylvania USA.
Arnur GusmanovDepartment of Epidemiology, School of Public Health University of Pittsburgh Pittsburgh Pennsylvania USA.
Aya HirataDepartment of Preventive Medicine and Public Health Keio University School of Medicine Tokyo Japan.ORCID https://orcid.org/0000-0003-1439-4242
Naoko MiyagawaDepartment of Preventive Medicine and Public Health Keio University School of Medicine Tokyo Japan.ORCID https://orcid.org/0000-0002-9148-1078
Naoki NakayaTohoku Medical Megabank Organization Tohoku University Sendai Miyagi Japan.ORCID https://orcid.org/0000-0002-1467-161X
Daisuke SugiyamaFaculty of Nursing and Medical Care Keio University Fujisawa Kanagawa Japan.ORCID https://orcid.org/0000-0002-6487-8934
Curtis TilvesDepartment of Epidemiology and Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center University of Colorado Aurora Colorado USA.ORCID https://orcid.org/0000-0003-0281-5986
Atsushi HozawaTohoku Medical Megabank Organization Tohoku University Sendai Miyagi Japan.
Xingnan LiUniversity of Hawai'i Cancer Center Honolulu Hawaii USA.
Noel T MuellerDepartments of Pediatrics and Epidemiology University of Colorado Aurora Colorado USA.
Panayiotis V BenosDepartment of Epidemiology, PHHP and COM University of Florida Gainesville Florida USA.ORCID https://orcid.org/0000-0003-3172-3132
Akira SekikawaDepartment of Epidemiology, School of Public Health University of Pittsburgh Pittsburgh Pennsylvania USA.ORCID https://orcid.org/0000-0002-7197-6321

Funding

Arterial Stiffness, Cognition, and Equol (ACE)R01AG074971 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AKIRA SEKIKAWA · 2022 to 2026
$12.7M
Integrative Model of Metabolomics, Equol and Atherosclerotic cardiovascular disease (IMMEA)R01HL169332 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PANAGIOTIS V BENOS, AKIRA SEKIKAWA · 2024 to 2026
$2.0M
NHLBI NIH HHS R01 HL169332NIA NIH HHS R01 AG074971
6 · The paper itself

Abstract

Soy isoflavones have been associated with benefits for menopausal symptoms, cardiovascular health, and cognitive function, yet randomized clinical trials (RCTs) in Western countries have produced inconsistent results. A key factor may be equol, a metabolite of daidzein with stronger estrogenic and antioxidant effects, produced at lower rates in Western than in East Asian populations. This systematic review evaluates RCTs aimed at converting equol nonproducers to producers (CRD420251038428). We searched PubMed, Embase, and Web of Science for RCTs published between 1991 and 2025. Twelve RCTs (

Indexed as

equolproducerrandomized clinical trialssoysystematic review

Identifiers

PMID42807573
PMCPMC13617254

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.