Evidence map›Paper›PMID 42807496›Full record

ArticleFrontiers in aging neuroscience2026

Tau-induced increase in promoter-proximal RNA polymerase II pausing is linked to suppressed expression of long neuronal genes in a

Kendall Cottingham, Nima Goodarzi, David Fries, Geethma Lirushie, Hana Hall

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kendall CottinghamBiochemistry Department, Purdue University, West Lafayette, IN, United States.
Nima GoodarziBiochemistry Department, Purdue University, West Lafayette, IN, United States.
David FriesBiochemistry Department, Purdue University, West Lafayette, IN, United States.
Geethma LirushieBiochemistry Department, Purdue University, West Lafayette, IN, United States.
Hana HallBiochemistry Department, Purdue University, West Lafayette, IN, United States.

Funding

Role of R-loops in transcriptional stress, genome instability, and chronic immune response in Alzheimer's diseaseR01NS135611 · NINDS · PURDUE UNIVERSITY · PI Hana Hall · 2023 to 2026
$1.9M
m6A RNA modification as a regulator of R-loop homeostasis and gene expression in aging and neurodegenerationR21AG077058 · NIA · PURDUE UNIVERSITY · PI HALL, HANA · 2022 to 2022
$375k
NIA NIH HHS R21 AG077058NINDS NIH HHS R01 NS135611
6 · The paper itself

Abstract

Tauopathies, including Alzheimer's disease, are age-related neurodegenerative disorders characterized by abnormal phosphorylation and buildup of microtubule-associated protein tau. Gene expression dysregulation is a key molecular feature of tauopathies, but how aging and disease interact to disrupt crucial transcriptional regulators and pathways remains largely unknown. Here, we examined how pathological tau affects gene expression programs in age-related neurodegenerative disease using a well-established

Indexed as

agingAlzheimer’s diseaseDrosophilagene expressionneurodegenerationpromoter-proximal pausingtauopathy

Identifiers

PMID42807496
PMCPMC13617067

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.