ArticleFrontiers in pediatrics2026
Integrated multi-omics analysis to explore correlations among cord blood IGF-1 levels, metabolomic profiles, and meconium gut microbiota in small-for-gestational-age neonates.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Small for gestational age (SGA) infants carry high risks of neonatal complications and lifelong metabolic disorders. This study explored correlations among cord blood IGF-1, cord blood metabolome, and meconium microbiota in SGA neonates to clarify the underlying pathophysiology. Methods: We consecutively recruited 113 term newborns (53 SGA, 60 AGA) delivered at Hainan Women and Children's Medical Centre from June 2024 to March 2025. Cord blood IGF-1 was tested via chemiluminescence. UHPLC-MS/MS untargeted metabolomics and 16S rRNA high-throughput sequencing were applied to characterize cord blood metabolites and meconium microbiota. Intergroup differences and partial Spearman correlations across IGF-1, metabolites, microbes and birth indices were analyzed, adjusting for gestational age, infant sex, and maternal delivery mode,where applicable. Results: (1) SGA infants had markedly lower cord blood IGF-1 ( Conclusions: SGA neonates feature suppressed IGF-1, intrauterine metabolic disorders and disordered initial gut colonization. Disturbed prenatal metabolism and pollutant exposure may jointly drive aberrant early microbiota development in growth-restricted newborns. The cross-sectional design precludes causal inference, and the chlorobenzene finding warrants independent validation.
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