Evidence map›Paper›PMID 42807304›Full record

ArticleInternational journal of medical sciences2026

Validation of Osteoporosis associated SNPs candidates from Decisive Gene Strategy using Taiwan Biobank.

Pei-Jan Tsai, Sin-Yu Lin, Meng-Chang Lee, Mei-Jung Chen, Chih-Chien Wang, Cheng-Jung Chen, Wei-Teing Chen, Po-Jen Hsiao, Chih-Chien Chiu, Yu-Hsuan Chen and 3 more

Abstract readValidation Study
PubMed Full text at PMC Publisher
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Article in International journal of medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

13 authors.

Pei-Jan TsaiGraduate Institute of Medical Sciences, College of Medicine, National Defense Medical University, Taipei 11490, Taiwan, R.O.C.
Sin-Yu LinGraduate Institute of Aerospace and Undersea Medicine, College of Biomedical Sciences, National Defense Medical University, Taipei 114201, Taiwan, R.O.C.
Meng-Chang LeeGraduate Institute of Public Health, College of Public Health, National Defense Medical University, Taipei 114201, Taiwan, R.O.C.
Mei-Jung ChenDepartment of Nursing, Tri-Service General Hospital, National Defense Medical University, Taipei 114202, Taiwan, R.O.C.
Chih-Chien WangSchool of Medicine, College of Medicine, National Defense Medical University, Taipei, Taiwan, R.O.C.
Cheng-Jung ChenDivision of General Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical University, Taipei 114202, Taiwan, R.O.C.
Wei-Teing ChenDivision of Thoracic Medicine, Department of Medicine, Cheng Hsin General Hospital, Taipei, Taiwan, R.O.C.
Po-Jen HsiaoSchool of Medicine, College of Medicine, National Defense Medical University, Taipei, Taiwan, R.O.C.
Chih-Chien ChiuDivision of Infectious Diseases, Department of Internal Medicine, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan, R.O.C.
Yu-Hsuan ChenGraduate Institute of Public Health, College of Public Health, National Defense Medical University, Taipei 114201, Taiwan, R.O.C.
Hsiao-Ting LinGraduate Institute of Public Health, College of Public Health, National Defense Medical University, Taipei 114201, Taiwan, R.O.C.
Hao SuGraduate Institute of Life Sciences, College of Biomedical Sciences, National Defense Medical University, Taipei 114201, Taiwan, R.O.C.
Sui-Lung SuGraduate Institute of Medical Sciences, College of Medicine, National Defense Medical University, Taipei 11490, Taiwan, R.O.C.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Decisive gene strategy (DGS) has been developed and identified 21 single nucleotide polymorphisms (SNPs) associated with osteoporosis (OP). This study aimed to further evaluate whether DGS is a suitable candidate strategy to identify the relationship between SNPs and OP using Taiwan Biobank (TWB). A total of 26,225 samples were retrieved from TWB between 2008 and 2021, comprising 4,749 osteoporosis (T-score ≤ -2.5) and 21,476 controls (T-score ≥ -1.0) based on their T-score of bone mineral density (BMD). Logistic regression analysis was used to examine the association between 21 SNPs from DGS and OP risk by using TWB data. The alignment of 21 SNPs from DGS with TWB genotyping chip found 11 identical SNPs. Among the 11 identical SNPs, seven showed results consistent with prior DGS evidence, including ESR1 rs9340799, OPG rs2073617, VDR rs731236, rs7975232, and rs1544410, IL6 rs1800795, and IGF1 rs5742612 [OR: 1.01, 1.03, 1.06, 1.01, 1.10, 0.72, 1.02; 95% CI= 0.94-1.09, 0.97-1.10, 0.93-1.22, 0.94-1.07, 0.97-1.26, 0.32-1.64, 0.96-1.09, respectively]. Furthermore, OPG T245G rs3134069 showed a borderline nominal association with osteoporosis in TWB [OR: 1.09, 95% CI= 1.00-1.19]), suggesting a potential population-specific signal. Our TWB validation of the 11 identical SNPs supports DGS as an effective methodology and, beyond replication, provides a novel framework for examining the relationship between SNPs and disease.

Indexed as

Genetic Predisposition to DiseaseOsteoporosisPolymorphism, Single NucleotideAgedBiological Specimen BanksBone DensityCase-Control StudiesEstrogen Receptor alphaFemaleHumansInsulin-Like Growth Factor IInterleukin-6MaleMiddle AgedOsteoprotegerinReceptors, CalcitriolESR1 protein, humanEstrogen Receptor alphaIGF1 protein, humanInsulin-Like Growth Factor IInterleukin-6OsteoprotegerinReceptors, CalcitriolTNFRSF11B protein, humanVDR protein, humandecisive gene strategyosteoporosissingle nucleotide polymorphismsTaiwan Biobank

Identifiers

PMID42807304
PMCPMC13617501

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.