ArticleFrontiers in medicine2026
Trends in mortality with osteoporosis recorded as the underlying cause of death among adults aged 65 years and older in the United States, 1999-2024.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Osteoporosis coded as the underlying cause of death increases mortality risk in older adults. This study aimed to examine temporal trends and demographic disparities in mortality with osteoporosis as the underlying cause of death among U.S. adults aged 65 years and older from 1999 to 2024, and to identify recent mortality plateauing patterns. Methods: A population-based retrospective ecological analysis was performed using the CDC WONDER national mortality database. All eligible decedents were restricted to adults ≥65 years with ICD-10 M80/M81 recorded as the underlying cause of death. Mortality counts, age-adjusted mortality rates (AAMR), crude mortality rates (CMR for age subgroups), and average annual percent change (AAPC) with 95% confidence intervals (CIs) were stratified by sex, census region, race/ethnicity, urbanization (limited to 1999-2020), and age group. Annual cells with death counts <10 were suppressed and excluded from continuous trend plotting. Joinpoint regression with pairwise AAPC Results: Total deaths with osteoporosis as the underlying cause decreased from 1,622 in 1999 to 484 in 2024 (-70.16%). The overall AAMR declined from 4.78 (95% CI: 4.54-5.01) to 0.92 (95% CI: 0.84-1.00), with an overall AAPC of -6.26 (95% CI: -7.37--5.14; Conclusions: Mortality with osteoporosis documented as the underlying cause of death presented a significant overall downward trend among U.S. adults aged 65 and older over 1999-2024, yet most subgroups exhibited plateauing mortality in recent calendar years. Continuous annual trend visualization for Hispanic populations is unfeasible due to CDC WONDER privacy suppression rules that hide records with fewer than 10 annual deaths, while complete aggregate summary statistics for Hispanic participants are reported. Females, the oldest-old population, and rural residents carried persistent excess mortality burden. These stratified nationwide epidemiological findings support targeted bone health public interventions for high-risk elderly subgroups.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.