ArticleFrontiers in immunology2026
Adipose-derived mesenchymal stem cell-exosomes attenuate lipopolysaccharide-induced acute lung injury in mice by regulating the TGFBR2/Smad4 axis to suppress NLRP3-mediated macrophage M1 polarization and pyroptosis.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study investigated whether adipose-derived mesenchymal stem cells-exosomes (ADMSC-Exo) alleviate lipopolysaccharide (LPS)-induced acute lung injury (ALI) by regulating NLRP3 inflammasome-mediated macrophage M1 polarization and pyroptosis through the miR-19b-3p/TGFBR2/Smad4 signaling axis. Methods: An LPS-induced mouse model of ALI was established and treated with ADMSC-Exo or adenoviral TGFBR2 overexpression (Ad-TGFBR2). Lung histopathology, lung wet-to-dry (W/D) weight ratio, macrophage polarization, and pyroptosis were evaluated. Results: ADMSC-Exo alleviated LPS-induced lung injury by preserving alveolar architecture and reducing lung injury scores and the W/D ratio. They inhibited M1 macrophage polarization and pyroptosis both Conclusion: ADMSC-derived exosomes alleviate LPS-induced acute lung injury by delivering miR-19b-3p to inhibit the TGFBR2/Smad4 signaling pathway, thereby suppressing NLRP3-mediated macrophage M1 polarization and pyroptosis and reducing lung epithelial cell apoptosis.
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