Novel circNSD2 promotes proliferation and testosterone synthesis while inhibiting apoptosis in bovine Leydig cells.

Xiang Meng, Tianxiang Meng, Xinqi Zhou, Sihua Jin, Yunhai Zhang, Ning Song, Hongyu Liu

Abstract read

In one paragraph

Article in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiang MengAnhui Province Key Laboratory of Local Livestock and Poultry Genetic Resource Conservation and Germplasm Innovation, College of Animal Science and Technology, Anhui Agricultural University, Hefei, China.

Tianxiang MengAnhui Province Key Laboratory of Local Livestock and Poultry Genetic Resource Conservation and Germplasm Innovation, College of Animal Science and Technology, Anhui Agricultural University, Hefei, China.

Xinqi ZhouAnhui Province Key Laboratory of Local Livestock and Poultry Genetic Resource Conservation and Germplasm Innovation, College of Animal Science and Technology, Anhui Agricultural University, Hefei, China.

Sihua JinAnhui Province Key Laboratory of Local Livestock and Poultry Genetic Resource Conservation and Germplasm Innovation, College of Animal Science and Technology, Anhui Agricultural University, Hefei, China.

Yunhai ZhangAnhui Province Key Laboratory of Local Livestock and Poultry Genetic Resource Conservation and Germplasm Innovation, College of Animal Science and Technology, Anhui Agricultural University, Hefei, China.

Ning SongAnhui Province Key Laboratory of Local Livestock and Poultry Genetic Resource Conservation and Germplasm Innovation, College of Animal Science and Technology, Anhui Agricultural University, Hefei, China.

Hongyu LiuAnhui Province Key Laboratory of Local Livestock and Poultry Genetic Resource Conservation and Germplasm Innovation, College of Animal Science and Technology, Anhui Agricultural University, Hefei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leydig cells (LCs) are the primary cells responsible for testosterone synthesis in male animals, and their steroidogenic function is crucial for testicular development and spermatogenesis in bulls. Circular RNAs (circRNAs) play important roles in various biological processes and reproductive development; however, their functions in bovine LCs remain largely unexplored. Our previous whole-transcriptome sequencing of calf and adult bovine testes identified a differentially expressed circRNA, circ_0027599 (designated circNSD2 after its host gene

Indexed as

apoptosisbovine Leydig cellscircNSD2proliferationtestosterone synthesis

Identifiers

PMID42807274

DOI10.3389/fvets.2026.1932131

PMCPMC13616769

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.