Evidence map›Paper›PMID 42807256›Full record

ArticleFrontiers in immunology2026

Longitudinal peripheral blood immune profiling reveals dynamic changes of five major immune cell lineages and their clinical associations in pediatric scrub typhus.

Yuanyuan Hua, Yushen He, Jimin Zhou, Yuxiang Yang, Xingming Xu, Yan Zhang, Shuai Zhang, Xianqiu Luo, Jing Hu, Kaiyan Yue and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yuanyuan HuaDepartment of Intensive Care Unit Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Chongqing, China.
Yushen HeCollege of Future Technology, Peking University, Beijing, China.
Jimin ZhouDepartment of Pediatrics, The First People's Hospital of Liangshan Prefecture, Xichang, China.
Yuxiang YangDepartment of Pediatrics, The First People's Hospital of Liangshan Prefecture, Xichang, China.
Xingming XuDepartment of Pediatrics, The First People's Hospital of Liangshan Prefecture, Xichang, China.
Yan ZhangDepartment of Pediatrics, Jin Yang County People's Hospital, Jinyang County, China.
Shuai ZhangDepartment of Clinical Laboratory, The First People's Hospital of Liangshan Prefecture, Xichang, China.
Xianqiu LuoDepartment of Pediatrics, Ning Nan County People's Hospital, Ningnan County, China.
Jing HuDepartment of Pediatrics, Ning Nan County People's Hospital, Ningnan County, China.
Kaiyan YueDepartment of Pediatrics, Hui Dong County People's Hospital, Huidong County, China.
Guolian ChenDepartment of Pediatrics, Hui Dong County People's Hospital, Huidong County, China.
Zuqun YangDepartment of Pediatrics, BuTuo County People's Hospital, Butuo County, China.
Rongju WenDepartment of Pediatrics, Mian Ning County People's Hospital, Mianning County, China.
Feng XuDepartment of Intensive Care Unit Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Chongqing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the dynamic changes of five major peripheral blood immune cell lineages during acute scrub typhus in children and their association with disease severity. Methods: A total of 141 children with clinically diagnosed scrub typhus were enrolled, including 100 mild and 41 severe cases. All children provided pretreatment immune samples, and 110 children with repeated post-treatment sampling contributed 299 observations to longitudinal immune analyses. Peripheral blood was collected at multiple time points, and the proportions and phenotypes of dendritic cells (DCs), monocytes, CD4 Results: Over the disease course, the proportion of HLA-DR Conclusion: This study systematically delineates the dynamic evolution of five major immune cell lineages during acute scrub typhus in children, describing immune alterations including a rapid increase of HLA-DR

Indexed as

Cell LineageDendritic CellsMonocytesOrientia tsutsugamushiScrub TyphusB-LymphocytesCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesChildChild, PreschoolFemaleHumansImmunophenotypingLongitudinal StudiesMaleSeverity of Illness Indexchildrendisease severitydynamic evolutionimmune cell subsetsscrub typhus

Identifiers

PMID42807256
PMCPMC13616781

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.