ArticleJournal of Cancer2026
Associations of
Article in Journal of Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Oral squamous cell carcinoma (OSCC) is a predominant malignancy of the oral cavity, with tongue squamous cell carcinoma (TSCC) accounting for a substantial proportion of cases worldwide. High-mobility group A protein 2 (HMGA2) is a nonhistone chromatin-binding factor implicated in aggressive malignant phenotypes of various human cancers. However, the effects of Methods: We examined the associations of functional Results: Our results indicated no significant association between the four SNPs and TSCC susceptibility. However, carriers of the rs6581658 G allele had significantly increased risks of large tumors (>T2) and advanced clinical stage (stage III or IV) in the dominant model. Moreover, the rs10573247 variant was significantly associated with an increased risk of lymph node metastasis in patients exposed to environmental carcinogens, including betel quid and cigarette smoke. By contrast, the rs968697 variant exerted a protective effect against advanced disease and lymph node metastasis in patients without such environmental exposure. Analyses of clinical datasets pertaining to an American cohort with head and neck squamous cell carcinoma and a Taiwanese cohort with OSCC revealed that HMGA2 expression was upregulated in tumor tissues and was associated with poor prognosis. Conclusion: These findings suggest potential exposure-stratified association in TSCC and highlight
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.