ArticleJournal of Cancer2026
Exosomes from Cancer-associated Fibroblasts Orchestrate Lung Metastasis of Breast Cancer via LncRNA LMAEP.
Article in Journal of Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lung metastasis is a leading cause of patient mortality in breast cancer. Cancer-associated fibroblasts (CAFs), the most abundant stromal cells within the tumor microenvironment, are closely implicated in pulmonary metastasis. Nevertheless, the mechanism underlying CAF-mediated metastasis remains elusive. We found that density of CAFs in primary tumors showed no significant difference in patients with or without lung metastasis. However, CAFs of breast cancer patients with lung metastasis (termed lung metastasis-associated fibroblasts, LMAFs) exhibited immense competence in inducing epithelial-mesenchymal transition (EMT), invasion and proliferation of tumor cells relative to non-metastatic CAFs. LMAF-derived exosomes were sufficient to confer the pro-metastatic phenotype to tumor cells. LncRNA microarray screening identified LMAEP (Lung Metastasis-Associated EMT Promoter) as a lncRNA specifically enriched in LMAF-derived exosomes. Knockdown of LMAEP abrogated the capacity of LMAFs to induce cancer cell EMT, invasion and proliferation. Targeting of lncRNA LMAEP tremendously suppressed tumor growth and lung metastasis of breast cancer
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.