ArticleFrontiers in microbiology2026
RefSeq-corrected transcriptomic and RNA-interaction integration maps medium-associated vancomycin response rewiring in
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Background: Materials and methods: In this secondary analysis, we performed a processed-expression reanalysis of public Results: In the exploratory GSE149213 processed-expression contrast analysis, analytically pooled vancomycin-evolved lineages/populations retained broad acute responses, with the strongest response-rewiring burden corresponding to the EVO-WT response shift in RPMI + 10% LB; EVO-MAC response shifts were much more limited. RefSeq locus-tag harmonization retained a predefined nine-locus candidate panel for evidence ranking. Conservative GSE254530 assessment provided strict cross-dataset differential-expression support for pyrR only, while glnA was uniquely mapped but not differentially expressed and the remaining seven candidates lacked conservative clean-feature mappings. RNase III-CLASH integration highlighted carbamoyl-P synthase, dihydroorotase and glnA as top-ranked candidate-associated CLASH hotspots. Module-level processed-expression analysis further localized evolved response shifts to RPMI-associated redox/stress, cell-wall/envelope and proteolysis/stress/virulence programs, with translation/ribosome showing a contrasting negative trend. Conclusion: This study provides a RefSeq-corrected, evidence-ranked processed-expression map of vancomycin response rewiring in
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