ArticleFrontiers in bioengineering and biotechnology2026
Hollow-degree-tuned Prussian blue-mesoporous silica nanoplatforms for chemo-photothermal cancer therapy with preliminary microfluidic perfusion evaluation.
Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Balancing photothermal performance and drug-delivery capacity remains a key challenge in the structural design of multifunctional nanomedicines. Hollowing can increase internal space for drug accommodation but may simultaneously reduce the amount of NIR-absorbing Prussian blue (PB), creating an inherent trade-off between drug-delivery capacity and photothermal performance. Methods: The hollow state of hollow mesoporous Prussian blue (HMPB) nanocubes was regulated by controlled HCl etching, followed by a common mesoporous silica (mSiO Results: Increasing hollowing enhanced DOX loading from 525 to 867 μg⋅mg Conclusion: These results demonstrate that hollow-state engineering provides a practical strategy for balancing competing photothermal and drug-delivery functions in PB-based nanoplatforms.
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