SynthesisFrontiers in cellular and infection microbiology2026
Evolution, disciplinary integration, and frontiers of multi-omics and single-cell technologies in periodontology: a bibliometric analysis (2000-2025) with an early-2026 frontier update.
Synthesis in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The field of periodontology is undergoing a paradigm shift from traditional microbiology to systems biology, driven by advancements in multi-omics and single-cell technologies. Despite the rapid surge in publications, a Web of Science Core Collection (WoSCC)-based bibliometric and scientometric analysis mapping the evolutionary trajectory and emerging frontiers of these technologies in periodontal research remains needed. We performed a bibliometric and scientometric analysis of literature published from 2000 to 2025, with records from early 2026 used only as an exploratory frontier update, using the Web of Science Core Collection (WoSCC). Data visualization and network analysis were conducted using VOSviewer, CiteSpace, and the R-bibliometrix package. Additionally, Latent Dirichlet Allocation (LDA) topic modeling was employed to extract underlying research themes from unstructured text data. A total of 559 eligible publications were identified, showing a marked growth trend. China and the United States emerged as the dominant contributors. The evolutionary trajectory was delineated into three distinct phases: foundational exploration, multi-omics integration, and the single-cell resolution era. LDA modeling identified nine core topics, focusing on local host-microbiome interactions, systemic interconnections, and periodontal regeneration-related research. Keyword bursts highlighted "single-cell RNA sequencing (scRNA-seq)," "microenvironment," and "macrophage polarization" as active current frontiers. The field appears to be transitioning within the WoSCC-indexed literature from descriptive microbiome studies toward functional multi-omics and single-cell-resolution analysis, providing an exploratory knowledge-map-based reference for future precision diagnostics and regenerative research in periodontology.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.