ArticleImmunity, inflammation and disease2026
Cell-Type-Specific HSPA1B Expression Links COPD and Atherosclerosis.
Article in Immunity, inflammation and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Cell-Type-Specific HSPA1B Expression Links COPD and Atherosclerosis.Immunity, inflammation and disease · 2026Article
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5 authors.
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Abstract
backgroundChronic obstructive pulmonary disease (COPD) and atherosclerosis frequently coexist, but their shared immune mechanisms remain incompletely understood.
methodsWe integrated single-cell RNA-sequencing datasets from COPD lungs and atherosclerotic lesions to characterize immune-cell composition, intercellular communication, and overlapping upregulated genes. Cell-type-specific sc-eQTL data from oneK1K were further combined with FinnGen GWAS summary statistics for COPD and coronary atherosclerosis using Mendelian randomization.
resultsBoth diseases showed a macrophage/monocyte-centered immune architecture, with macrophages serving as major communication hubs. Among overlapping genes evaluated genetically, HSPA1B showed consistent associations across both diseases. Genetically predicted HSPA1B expression in classical monocytes was positively associated with COPD and coronary atherosclerosis, whereas expression in non-classical monocytes showed inverse associations. NK cell-specific HSPA1B expression was also positively associated with COPD.
conclusionCOPD and atherosclerosis share myeloid-centered immune features, and HSPA1B may represent a cell-state-dependent immune signal linking pulmonary and vascular inflammation.
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