Evidence map›Paper›PMID 42806865›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

AARS2-SIRT5-Driven DLD K445 Lactylation Promotes Cuproptosis Resistance in Glioblastoma Stem Cells.

Mingtian Ding, Haibiao Xu, Cen Liu, Yangyin Ding, Shuai Wang, Jun Yin, Tao Fu, Xiao Jiang, Yuning Chen, Hui Luo and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mingtian Ding *Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0009-0007-5975-2329
Haibiao Xu *Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0009-0001-5130-2629
Cen Liu *Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Yangyin Ding *Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Shuai Wang *Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Jun YinDepartment of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0009-0004-9786-213X
Tao FuDepartment of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Xiao JiangDepartment of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Yuning ChenDepartment of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Hui LuoDepartment of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Rui LiDepartment of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Zhengxin ChenDepartment of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Huibo WangDepartment of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Funding

Major Basic Research Fund of Jiangsu Province Hospital TS202405National Natural Science Foundation of China 82273164National Natural Science Foundation of China 82573129
6 · The paper itself

Abstract

Therapy-resistant glioblastoma stem cells (GSCs) drive tumor progression and recurrence in glioblastoma (GBM). Cuproptosis is a copper-dependent form of regulated cell death triggered by aggregation of lipoylated mitochondrial proteins, but the mechanisms underlying cuproptosis resistance in GSCs remain unclear. Lactylome profiling identifies dihydrolipoamide dehydrogenase (DLD) as a key lactylation target regulating cuproptosis. Mechanistically, lactate-dependent alanyl-tRNA synthetase 2 (AARS2) catalyzes DLD K445 lactylation, while SIRT5 reverses this modification via NAD

Indexed as

cuproptosisglioblastoma stem cellslactylation

Identifiers

PMID42806865
PMCPMC13621201

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.