ReviewBiochemical Society transactions2026
HELQ & Hel308: ancient enzymes of DNA repair and recombination.
Review in Biochemical Society transactions, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
We highlight the multifunctionality of the Hel308 and HELQ Ski2-like 'helicases' as they toggle between DNA annealing and DNA translocation across multiple DNA repair pathways. Defects in Hel308/HELQ cause genetic instability, including dysregulated homologous recombination. New data reveal how Hel308 and HELQ switch between DNA translocation and annealing, a mechanism that may restrain recombination to short tracts by curbing extensive DNA synthesis. We describe a PWI-like innovation in HELQ that evolved in bilaterian animals-absent from other animals and archaea-which we propose is an ATR-targeted phosphoregulatory module, coordinating protein interactions and, through those, DNA repair-recombination reactions. The overall picture is of Hel308 and HELQ as ancient DNA annealing enzymes, aided by short bursts of ATP-powered DNA translocation, kept in balance by molecular switches and the additional regulatory surfaces that arose in some animals.
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