ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Targeting Macrophage-Mediated Lymphatic Immunosuppression to Prevent Tumor Recurrence After Microwave Ablation.
Xuexia Shan, Yuting Shen, Xiaodong Hou, Fengshan Jin, Shaoyue Li, Weichen Xu, Weiwei Ren, Xiaowan Bo, Qiuyan Li, Shuo Liu and 5 more
Abstract read
In one paragraphArticle in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
15 authors.
Xuexia ShanDepartment of Medical Ultrasound, Center of Minimally Invasive Treatment for Tumor, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, P. R. China.ORCID https://orcid.org/0009-0006-2797-6486 Yuting ShenDepartment of Ultrasound, Zhongshan Hospital, Institute of Ultrasound in Medicine and Engineering, Fudan University, Shanghai, P. R. China.
Xiaodong HouDepartment of Ultrasound, Shenzhen Maternity and Child Healthcare Hospital, Women and Children's Medical Center, Southern Medical University, Shenzhen, P. R. China.
Fengshan JinDepartment of Medical Ultrasound, Center of Minimally Invasive Treatment for Tumor, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, P. R. China.ORCID https://orcid.org/0000-0003-2207-4505 Shaoyue LiDepartment of Medical Ultrasound, Center of Minimally Invasive Treatment for Tumor, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, P. R. China.ORCID https://orcid.org/0009-0006-3180-6607 Weichen XuDepartment of Medical Ultrasound, Center of Minimally Invasive Treatment for Tumor, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, P. R. China.
Weiwei RenDepartment of Medical Ultrasound, Center of Minimally Invasive Treatment for Tumor, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, P. R. China.
Xiaowan BoDepartment of Medical Ultrasound, Center of Minimally Invasive Treatment for Tumor, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, P. R. China.ORCID https://orcid.org/0000-0001-9879-7115 Qiuyan LiDepartment of Medical Ultrasound, Center of Minimally Invasive Treatment for Tumor, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, P. R. China.
Shuo LiuDepartment of Medical Ultrasound, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China.
Weifan HaoThe First Hospital of Anhui University of Science & Technology, Anhui University of Science and Technology, Huainan, P. R. China.
Chengzhong PengDepartment of Medical Ultrasound, Center of Minimally Invasive Treatment for Tumor, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, P. R. China.ORCID https://orcid.org/0000-0003-4886-7466 Liping SunDepartment of Medical Ultrasound, Center of Minimally Invasive Treatment for Tumor, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, P. R. China.ORCID https://orcid.org/0000-0002-4301-4520 Wenwen YueDepartment of Medical Ultrasound, Center of Minimally Invasive Treatment for Tumor, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, P. R. China.ORCID https://orcid.org/0000-0002-7121-591X Funding
National Natural Science Foundation of China 82171943Natural Science Foundation of Shanghai 23ZR1449600Postdoctoral Science Foundation of Heilongjiang Province LBH-Z25222Shanghai Anticancer Association EYAS PROJECT SACA-CY25B06
6 · The paper itselfAbstract
Microwave ablation (MWA) is an effective locoregional therapy for solid tumors, but recurrence caused by minimal residual disease remains a clinical challenge. Although immunotherapy offers a strategy to prevent recurrence, the role of tumor-draining lymph nodes (TDLNs) in post-ablation immune regulation remains underexplored. Here, single-cell RNA sequencing (scRNA-seq) reveals pronounced macrophage remodeling in TDLNs following incomplete MWA (iMWA), characterized by an increased representation of immunosuppressive Folr2
Indexed as
drug deliveryimmune microenvironmentlymph nodesmicrowave ablationtumor immunotherapy
Identifiers
PMID42806500
PMCPMC13620260
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