Evidence map›Paper›PMID 42806388›Full record

ArticleAllergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology2026

Vespula spp. venom immunotherapy: basophil excitability and Fc

Janik Fleissner, Johanna Stoevesandt, Matthias Goebeler, Axel Trautmann, Andreas Kerstan

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Article in Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Janik FleissnerDepartment of Dermatology, Venereology, and Allergology, University Hospital Würzburg, Josef-Schneider-Str. 2, D-97080, Würzburg, Germany. fleissner_j@ukw.de.ORCID https://orcid.org/0009-0000-1435-0245
Johanna StoevesandtDepartment of Dermatology, Venereology, and Allergology, University Hospital Würzburg, Josef-Schneider-Str. 2, D-97080, Würzburg, Germany.
Matthias GoebelerDepartment of Dermatology, Venereology, and Allergology, University Hospital Würzburg, Josef-Schneider-Str. 2, D-97080, Würzburg, Germany.
Axel TrautmannDepartment of Dermatology, Venereology, and Allergology, University Hospital Würzburg, Josef-Schneider-Str. 2, D-97080, Würzburg, Germany.
Andreas KerstanDepartment of Dermatology, Venereology, and Allergology, University Hospital Würzburg, Josef-Schneider-Str. 2, D-97080, Würzburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBasophils are recognized as important effector cells during the sensitization and effector phases of IgE-mediated allergy. Besides histamine release during anaphylaxis, basophils contribute to early immune polarization as an important source of Th2-associated cytokines. Vespula spp. venom immunotherapy (VIT) represents a prime example of clinically highly effective allergen-specific immunotherapy. This study investigated functional and phenotypic changes in circulating basophils during early VIT in a homogenous case series.

methodsTwenty-four patients eligible for VIT were examined before treatment, after 3 days, and after 1 month of therapy. Basophils were primed with interleukin-(IL-)3 and stimulated with IgE-dependent triggers, including Vespula spp. venom and an anti-IgE antibody, as well as the IgE-independent bacterial peptide N-formylmethionyl-leucyl-phenylalanine (fMLP). Basophil activation was assessed by flow cytometric measurement of CD63 expression. In parallel, Fc

resultsAfter one month of VIT, venom-specific basophil excitability was significantly reduced. In contrast, activation by anti-IgE and fMLP remained largely unchanged. An increase of both Fc

conclusionsData of this study suggest that upregulation of Fc

Indexed as

Basophil activation testHymenoptera venom allergyImmune toleranceVenom immunotherapy

Identifiers

PMID42806388
PMCPMC13617696

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