SynthesisBMC infectious diseases2026
Lipid profile alterations in pulmonary tuberculosis patients with and without diabetes mellitus: a systematic review and meta-analysis.
Synthesis in BMC infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
backgroundThis systematic review and meta-analysis explored lipid alterations associated with tuberculosis-diabetes comorbidity. We quantitatively synthesised the lipid parameters, comparing high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, and total cholesterol among patients with TB-DM comorbidity, TB-only, and DM-only.
methodsFollowing PRISMA guidelines and a registered protocol (PROSPERO: CRD420261355915), we searched PubMed (n = 150), Scopus (n = 679), and Google Scholar (n = 70) through April 7, 2026. Observational studies reporting lipid parameters were included. Methodological quality was appraised using the Newcastle-Ottawa Scale, and certainty of evidence was evaluated using GRADE. Pooled mean differences and pooled means were estimated using random-effects models, with between-study variance estimated by REML and Hartung-Knapp-adjusted confidence intervals. Heterogeneity was quantified using the I
resultsNine studies comprising 1,494 participants were included. Compared to the TB-only group, patients with TB-DM exhibited higher concentrations of LDL-C (MD = 14.99 mg/dL; 95% CI: 1.28-28.71), TG (MD = 30.13 mg/dL; 95% CI: 17.58-42.67), and TC (MD = 17.29 mg/dL; 95% CI: 5.42-29.16), while HDL-C showed no significant difference (MD = -1.15 mg/dL; 95% CI: -5.07-2.77). A principal sensitivity analysis showed that TG elevation remained robust, whereas LDL-C and TC findings lost statistical significance. In the secondary comparison, TB-DM patients exhibited significantly lower concentrations across all four lipid parameters relative to the DM-only group. Heterogeneity was substantial for the primary comparison (I
conclusionThe findings suggest that TB-DM may be associated with a higher TG concentration compared to patients with TB alone. Significant associations with LDL-C and TC were also observed but were not robust to sensitivity analyses, while no significant difference was found for HDL-C. Conversely, TB-DM may be associated with a relative reduction in HDL-C, LDL-C, TG, and TC compared to DM-only.
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