Evidence map›Paper›PMID 42806306›Full record

ArticleMolecular medicine (Cambridge, Mass.)2026

NETs drive CD4⁺ T cell dysfunction in sepsis via mitochondrial ROS and impaired calcium signalling.

Hongru Li, Xuan Wang, Keran Sun, Jiachao Wang, Jiao Li, Enhao Zhang, Xiaoqing Li, Changwei Su, Zixin Li, Yushan Lin and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine (Cambridge, Mass.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Hongru LiDepartment of Immunology, Key Laboratory of Immune Mechanism and Intervention On Serious Disease in Hebei Province, Hebei Medical University, Shijiazhuang, 050017, China.
Xuan WangDiagnostic Center of Infections, The Second Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China.
Keran SunDepartment of Immunology, Key Laboratory of Immune Mechanism and Intervention On Serious Disease in Hebei Province, Hebei Medical University, Shijiazhuang, 050017, China.
Jiachao WangDepartment of Immunology, Key Laboratory of Immune Mechanism and Intervention On Serious Disease in Hebei Province, Hebei Medical University, Shijiazhuang, 050017, China.
Jiao LiDepartment of Immunology, Key Laboratory of Immune Mechanism and Intervention On Serious Disease in Hebei Province, Hebei Medical University, Shijiazhuang, 050017, China.
Enhao ZhangDepartment of Immunology, Key Laboratory of Immune Mechanism and Intervention On Serious Disease in Hebei Province, Hebei Medical University, Shijiazhuang, 050017, China.
Xiaoqing LiDepartment of Immunology, Key Laboratory of Immune Mechanism and Intervention On Serious Disease in Hebei Province, Hebei Medical University, Shijiazhuang, 050017, China.
Changwei SuDepartment of Immunology, Key Laboratory of Immune Mechanism and Intervention On Serious Disease in Hebei Province, Hebei Medical University, Shijiazhuang, 050017, China.
Zixin LiDepartment of Immunology, Key Laboratory of Immune Mechanism and Intervention On Serious Disease in Hebei Province, Hebei Medical University, Shijiazhuang, 050017, China.
Yushan LinDepartment of Immunology, Key Laboratory of Immune Mechanism and Intervention On Serious Disease in Hebei Province, Hebei Medical University, Shijiazhuang, 050017, China.
Miao LiDepartment of Immunology, Key Laboratory of Immune Mechanism and Intervention On Serious Disease in Hebei Province, Hebei Medical University, Shijiazhuang, 050017, China.
Xiurong WangDepartment of Immunology, Key Laboratory of Immune Mechanism and Intervention On Serious Disease in Hebei Province, Hebei Medical University, Shijiazhuang, 050017, China.
Hong ZhangHebei Key Laboratory of Intractable Pathogens, Shijiazhuang Center for Disease Control and Prevention, Shijiazhuang, Hebei, China.
Chenhui LiHebei Key Laboratory of Autoimmune Disease Medicine Research, Shijiazhuang, 050035, China.
Lin WeiDepartment of Immunology, Key Laboratory of Immune Mechanism and Intervention On Serious Disease in Hebei Province, Hebei Medical University, Shijiazhuang, 050017, China. weilin@hebmu.edu.cn.
Cuiqing MaDepartment of Immunology, Key Laboratory of Immune Mechanism and Intervention On Serious Disease in Hebei Province, Hebei Medical University, Shijiazhuang, 050017, China. macuiqing@hebmu.edu.cn.

Funding

Hebei Key R&D Program Project Special Project for the Construction of Beijing-Tianjin-Hebei Collaborative Innovation Community 22347702DNatural Science Youth Foundation of Hebei Province H2024206108the central government guides local funds for science and technology development 246Z7709G
6 · The paper itself

Abstract

backgroundSepsis is a life-threatening condition with high mortality, in which sepsis-induced immunosuppression-characterized by CD4

methodsWe integrated plasma analysis from 50 sepsis patients and 31 healthy controls, a murine cecal ligation and puncture (CLP) sepsis model, and in vitro assays with Jurkat cells and primary CD4

resultsCirculating NETs were significantly elevated in sepsis patients, positively correlated with disease severity (SOFA score) and negatively correlated with peripheral CD4

conclusionThe NETs-mtROS axis represents an important pathway driving CD4

Indexed as

Calcium SignalingCD4-Positive T-LymphocytesExtracellular TrapsMitochondriaReactive Oxygen SpeciesSepsisAnimalsApoptosisCalciumDeoxyribonuclease IDisease Models, AnimalFemaleHumansJurkat CellsMaleMembrane Potential, MitochondrialCalciumDeoxyribonuclease IMitoTEMPOOrganophosphorus CompoundsPiperidinesReactive Oxygen SpeciesCD4 + T cellsImmunosuppressionMitochondrial dysfunctionNETsSepsis

Identifiers

PMID42806306
PMCPMC13621543

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.