ArticleJournal of general internal medicine2026
Pain and Opioid Dose Reduction Based on Substance Use Disorder Status: Secondary Analysis from a Pragmatic Effectiveness Trial.
Article in Journal of general internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03026790 (Comparative Effectiveness of Patient-Centered Strategies to Improve Pain Management and Opioid Safety for Veterans), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparative Effectiveness of Patient-Centered Strategies to Improve Pain Management and Opioid Safety for Veterans
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
backgroundCo-occurring substance use disorder (SUD) is common among patients with chronic pain prescribed long-term opioid therapy (LTOT); unfortunately, limited empirical data are available to guide treatment.
objectiveOur goal was to examine the extent to which baseline SUD status was associated with changes in pain interference, pain intensity, and prescription opioid dose reduction.
designThe present results are a secondary analysis of a pragmatic multisite 12-month randomized comparative effectiveness trial.
participantsEligible patients included veterans who were receiving LTOT for treatment of chronic pain.
interventionsParticipants were randomized to receive one of two interventions, both of which were based on the collaborative care model for chronic pain; the interventions differed by resource intensity and included an intensive interdisciplinary pain team or less resource intensive pharmacist collaborative management. For these analyses, the treatment conditions were collapsed and we examined the extent to which SUD status at baseline predicted treatment outcomes. MAIN MEASURES: Primary outcomes were changes at 12 months in pain interference, pain intensity, and prescription opioid dose. KEY
resultsAt baseline, 250 of 778 participants (32.1%) met criteria for potential SUD. Participants with potential SUD were younger and more likely to have co-occurring mental health diagnoses, compared to participants without SUD, though had no differences in pain interference, pain intensity, or prescription opioid dose. During treatment, participants in both the potential SUD and No SUD group had significant reductions in pain interference and pain intensity, as well as reductions in prescription opioid dose. In adjusted analyses, there was no difference between groups in change on any of these outcomes.
conclusionsParticipants with and without potential SUD experienced improvements in pain interference and pain intensity, and had reductions in prescription opioid dose. These results suggest SUD status does not inhibit treatment response to collaborative care interventions for chronic pain. TRIALS REGISTRATION: ClinicalTrials.gov: NCT03026790.
Indexed as
Identifiers
42806226What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.