ArticleArchives of gynecology and obstetrics2026
Expression patterns of circulating microRNA in confirmed early-onset and late-onset pre-eclampsia cases.
Article in Archives of gynecology and obstetrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeThe aim of our study was to investigate selected pre-eclampsia (PE)-related miRNAs in clearly defined early- and late-onset PE (eoPE, loPE) cohorts and compare them with healthy controls.
methodsThis is a single-center, pilot study comparing pregnancies with eoPE (n=10) and loPE (n=8), each with separate healthy controls (n=10; n=8). Serum miRNA (miR-) expression levels of selected PE-associated miRNAs (miR-210-3p, miR-518b) were quantified by real-time PCR.
resultsSimilar expression profiles (delta CT ± standard deviation) were observed between loPE vs. controls: miR-210-3p (8.20 ± 1 vs. 7.48 ± 1.2; p=0.16; Hodges-Lehmann estimator (HL): - 0.73, 95% confidence interval (CI) - 2.2 to 0.78) and miR-518b (9.82 ± 1.1 vs. 9.60 ± 0.9; p=0.80, HL: - 0.14, 95% CI - 1.61 to 0.91). Comparing eoPE cases to controls, we found an increase of miR-210-3p concentration (7.63 ± 1.1 vs. 9.31 ± 1.9; p=0.019; HL: 1.23, 95% CI 0.15 to 2.66, mean fold change: 3.2; sensitivity analysis: p=0.067) and a numerical difference in miR-518b expression without reaching statistical significance (8.77 ± 1.4 vs. 9.85 ± 1.8; p=0.19; HL: 0.70, 95% CI - 0.33 to 2.41; mean fold change: 2.1).
conclusionIn the eoPE, miR-210-3p levels were higher than in controls, with the same trend observed in the sensitivity analysis, although statistical significance was no longer reached (p=0.067). miR-518b showed a numerical, non-significant difference between eoPE and controls. No significant differences were observed in loPE. Given the small sample size and overlap with early-onset fetal growth restriction, these findings should be considered exploratory.
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