Evidence map›Paper›PMID 42806091›Full record

ArticleNature cell biology2026

Cell atlas of the developing human meninges reveals a dura-like nature of meningiomas.

Elin Vinsland, Sergio Marco Salas, Ivana Kapustová, Lijuan Hu, Simone Webb, Xiaofei Li, Xiaoling He, Mats Nilsson, Muzlifah Haniffa, Roger A Barker and 5 more

Abstract read
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Article in Nature cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Elin VinslandLaboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Biomedicum, Karolinska Institutet, Stockholm, Sweden. elin.vinsland@gmail.com.ORCID http://orcid.org/0000-0001-9695-9192
Sergio Marco SalasScience for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
Ivana KapustováLaboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Biomedicum, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0009-0006-9599-757X
Lijuan HuLaboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Biomedicum, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-1869-0372
Simone WebbBiosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Xiaofei LiDivision of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.ORCID http://orcid.org/0000-0002-9991-7534
Xiaoling HeJohn van Geest Centre for Brain Repair, Department of Clinical Neurosciences, Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0009-0004-1002-8418
Mats NilssonScience for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-9985-0387
Muzlifah HaniffaWellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0002-3927-2084
Roger A BarkerJohn van Geest Centre for Brain Repair, Department of Clinical Neurosciences, Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-8843-7730
Oscar PerssonDepartment of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
David R RaleighDepartment of Radiation Oncology, Department of Neurological Surgery, Department of Pathology, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-9299-8864
Erik SundströmDivision of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.ORCID http://orcid.org/0000-0003-2931-8015
Peter LönnerbergLaboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Biomedicum, Karolinska Institutet, Stockholm, Sweden.
Sten LinnarssonLaboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Biomedicum, Karolinska Institutet, Stockholm, Sweden. sten.linnarsson@ki.se.ORCID http://orcid.org/0000-0002-3491-3444

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The vertebrate central nervous system is enveloped by the meninges, consisting of the pia, arachnoid and dura layers. The arachnoid is hypothesized to give rise to the most common primary intracranial tumours, meningiomas. However, supporting molecular evidence is lacking. There are no effective medical therapies to treat meningiomas that are resistant to local interventions, encumbered by our limited understanding of their cellular origin. Here, to advance our understanding of meningioma biology, we generated a comprehensive reference single-cell and spatial transcriptomic atlas of human fetal meninges at postconceptional weeks 5-13. We found that the meningeal layers develop concurrently, and identified an inner CDH1-positive dura layer expressing tight-junction genes consistent with barrier function. Comparing meningiomas with fetal meninges, we show that, transcriptionally, meningioma cells resemble dura-lineage cells, and that common meningioma driver genes were expressed in the dura lineage. This raises the hypothesis that meningiomas could originate from dura-lineage cells.

Identifiers

PMID42806091

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.