Evidence map›Paper›PMID 42806043›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2026

Randomized pilot study comparing standard vs high-calorie feeding in infants with Neonatal Opioid Withdrawal Syndrome.

Frances Y Cheng, McKenzie Tuttle, Elyssa Dionne, Veronika Shabanova, Sarah McCollum, Alyssa Morrison, Chandler J McMillan, Sandra N Anyoha, Lynda S Swerling, Amy Petrucelli and 9 more

Registry-linked trialAbstract read
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In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04419857 (A Randomized Control Trial to Determine Weight Gain Benefits of Caloric Supplementation for NAS Infants), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04419857 nacompletednot on this map

A Randomized Control Trial to Determine Weight Gain Benefits of Caloric Supplementation for NAS Infants

TypeinterventionalSponsorYale UniversityRan2020 to 2025Enrolled39ConditionsNeonatal Abstinence SyndromeArmsHigh-calorie formula
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Frances Y ChengDepartment of Pediatrics, Yale University School of Medicine, New Haven, CT, USA. frances.cheng@yale.edu.ORCID http://orcid.org/0000-0001-8255-8689
McKenzie Tuttle *Ann and Robert H. Lurie Children's Hospital of Chicago/Northwestern University, Chicago, IL, USA.ORCID http://orcid.org/0009-0006-8874-884X
Elyssa Dionne *Yale University School of Medicine, New Haven, CT, USA.
Veronika ShabanovaDepartment of Pediatrics, Yale University School of Medicine, New Haven, CT, USA.
Sarah McCollumDepartment of Pediatrics, Yale University School of Medicine, New Haven, CT, USA.
Alyssa MorrisonDuke University Medical Center, Durham, NC, USA.
Chandler J McMillanUniversity of California San Francisco, San Francisco, CA, USA.
Sandra N AnyohaDepartment of Pediatrics, Yale University School of Medicine, New Haven, CT, USA.
Lynda S SwerlingDivision of Pediatrics, Lawrence and Memorial Hospital, New London, CT, USA.
Amy PetrucelliDepartment of Pediatrics, Yale University School of Medicine, New Haven, CT, USA.
Lauren K LaryDivision of Pediatrics, Lawrence and Memorial Hospital, New London, CT, USA.
Kristen FultonDivision of Pediatrics, Lawrence and Memorial Hospital, New London, CT, USA.
Dhatri AbeyaratneBoston Children's Hospital, Boston, MA, USA.
Grace WangDepartment of Medicine, University of Washington, Seattle, WA, USA.
Christine HodelinYale University School of Medicine, New Haven, CT, USA.
Lina A ElmansyBoston Children's Hospital, Boston, MA, USA.
Kailey CarlsonVirginia Mason Franciscan Health/St. Michael Medical Center, Bremerton, WA, USA.
Eugene D ShapiroDepartment of Pediatrics, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-4130-3468
Matthew R GrossmanDepartment of Pediatrics, Yale University School of Medicine, New Haven, CT, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe assessed feasibility of high-calorie feeds in infants with NOWS at risk for excessive weight loss managed using Eat, Sleep, Console. STUDY

designIn this double-blind pilot study (NCT04419857, Connecticut, USA), we randomized methadone- or buprenorphine-prenatally-exposed infants <48 h old to standard- or high-calorie feeds. Primary outcomes were enrollment, adherence, and retention; exploratory outcomes included breastfeeding and stooling frequency.

resultsFrom December 2020 to August 2023, 35/65 infants (53.8%) were randomized. During hospitalization, 84% of feeds adhered to the randomized feeding approach. In-hospital retention was 71.4%; 14-day post-discharge retention was 28.6%. Groups did not differ significantly in demographic characteristics, maximum percent weight loss (p = 0.12), length of stay (p = 0.88), or stool frequency (p = 0.59). High-calorie-fed infants more frequently received breastmilk at discharge (p = 0.04).

conclusionEnrollment, adherence, and in-hospital retention were comparable to other feasibility trials; post-discharge follow-up was poor. Early high-calorie feeding did not appear to be negatively associated with breastfeeding or stooling.

Identifiers

PMID42806043

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.