Evidence map›Paper›PMID 42806003›Full record

ArticleNature communications2026

CD38-activated macrophages drive age-related placental senescence by depleting NAD

Lun Hua, Xiaohan Yang, Dengfeng Gao, Xintong Yang, Xianyang Jin, Lulu Ma, Wenting Liu, Jing Li, Zhaoli Shen, Luting Liu and 18 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Lun Hua *Animal Nutrition Institute, Sichuan Agricultural University, Chengdu, China.
Xiaohan Yang *Animal Nutrition Institute, Sichuan Agricultural University, Chengdu, China.ORCID 0009-0008-6651-6022
Dengfeng Gao *State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, China.ORCID 0000-0002-5180-0775
Xintong Yang *State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, China.
Xianyang JinAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, China.
Lulu MaAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, China.
Wenting LiuDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Jing LiState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, China.
Zhaoli ShenCollege of Science, Sichuan Agricultural University, Ya'an, China.ORCID 0000-0002-6244-9298
Luting LiuAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, China.
Yanni WuAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, China.
Yi YangAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, China.
Chunli ZhuState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, China.
Litong LiState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, China.
Xuemei JiangAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, China.
Xingfa HanSchool of Life Sciences, Sichuan Agricultural University, Chengdu, China.
Chao JinAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, China.
Guangmang LiuAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, China.
Bin FengAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, China.ORCID 0000-0001-6258-2729
Lianqiang CheAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, China.
Shengyu XuAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, China.
Yan LinAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, China.
Zhengfeng FangAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, China.
Long JinState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, China.ORCID 0000-0002-6055-4692
Ting LuoState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, China. ting.luo@ncu.edu.cn.ORCID 0000-0002-3394-7861
Yong ZhuoAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, China. zhuoyong@sicau.edu.cn.ORCID 0000-0002-8348-4199
Mingzhou LiState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, China. mingzhou.li@sicau.edu.cn.ORCID 0000-0001-8681-7684
De WuAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, China. wude@sicau.edu.cn.ORCID 0000-0003-1873-9914

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32230102,32225046, 32421005,32494802,32472948,
6 · The paper itself

Abstract

As delayed childbearing becomes increasingly common, elucidating the mechanisms of age-related placental senescence is critical for the development of effective therapeutic strategies. Here, we integrate metabolomics, single-cell RNA sequencing, and spatial transcriptomics to uncover conserved features of aged placentas in humans, mice, and pigs, namely, increased macrophage CD38 expression and NAD⁺ deficiency. Through pharmacological and genetic approaches, we demonstrate that macrophage CD38 depletes NAD⁺ in decidual stromal cells, thereby promoting placental senescence. Mechanistically, early-onset inflammation and senescence-associated secretory phenotype activity drive CD38 expression in macrophages via the IRF5 pathway. Importantly, treatment with NAD⁺ precursors or CD38 inhibitors attenuates age-related placental senescence, rescues intrauterine growth restriction, and improves long-term metabolic outcomes in offspring. These findings reveal a critical role for macrophage-driven metabolic dysregulation in reproductive aging and establish CD38 as a potential therapeutic target for age-associated pregnancy complications.

Indexed as

ADP-ribosyl Cyclase 1AgingCellular SenescenceDeciduaMacrophagesMembrane GlycoproteinsNADPlacentaStromal CellsAnimalsFemaleFetal Growth RetardationHumansInterferon Regulatory FactorsMacrophage ActivationMiceADP-ribosyl Cyclase 1Interferon Regulatory FactorsMembrane GlycoproteinsNAD

Identifiers

PMID42806003
PMCPMC13620170

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.