Evidence map›Paper›PMID 42805971›Full record

ArticleNature communications2026

Woven dECM yarn scaffolds enable volumetric muscle loss regeneration via immunomodulation.

Guangzhou Song, Wenqian Cong, Hongjiang Lu, Yumeng Wang, Yanzhen Zhao, Shaowen Wang, Shijie Zhu, Meng Fan, Deling Kong, Kai Wang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Guangzhou SongCollege of Life Sciences, Key Laboratory of Bioactive Materials, Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, China.
Wenqian CongCollege of Life Sciences, Key Laboratory of Bioactive Materials, Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, China.
Hongjiang LuCollege of Life Sciences, Key Laboratory of Bioactive Materials, Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, China.
Yumeng WangCollege of Life Sciences, Key Laboratory of Bioactive Materials, Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, China.
Yanzhen ZhaoCollege of Life Sciences, Key Laboratory of Bioactive Materials, Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, China.
Shaowen WangCollege of Life Sciences, Key Laboratory of Bioactive Materials, Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, China.
Shijie ZhuCollege of Life Sciences, Key Laboratory of Bioactive Materials, Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, China.
Meng FanTianjin First Center Hospital, Tianjin, 300192, China.
Deling KongCollege of Life Sciences, Key Laboratory of Bioactive Materials, Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, China.ORCID http://orcid.org/0000-0002-2961-9267
Kai WangCollege of Life Sciences, Key Laboratory of Bioactive Materials, Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, China. 013053@nankai.edu.cn.ORCID http://orcid.org/0000-0003-3317-3509
Xin ZhouKey Laboratory of Cellular Physiology at Shanxi Medical University, Ministry of Education, and School of Basic Medical Sciences, Shanxi Medical University, Taiyuan, 030001, China. xzhou@sxmu.edu.cn.ORCID http://orcid.org/0000-0003-0537-9681
Meifeng ZhuCollege of Life Sciences, Key Laboratory of Bioactive Materials, Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, China. zhumeifeng@nankai.edu.cn.ORCID http://orcid.org/0000-0002-5520-0769

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Volumetric muscle loss (VML) represents a significant unmet clinical need in current medical practice. Decellularized extracellular matrix (dECM) offers a promising clinical approach. However, its inherent architecture impedes adaptive topological guidance for rapid cellular infiltration, spatial organization, and coordinated immune response, limiting functional restoration. Here, we report a dECM yarn scaffold (YS) fabricated by 3D weaving of rotary-cut yarns, achieving precise structural control, full interconnectivity and high porosity. In murine VML models, YS significantly improved vascularization, innervation, muscle mass, and strength restoration. Single-nucleus RNA-sequencing identified decreased SPP1

Indexed as

Decellularized Extracellular MatrixImmunomodulationMuscle, SkeletalRegenerationTissue ScaffoldsAnimalsDogsFemaleInsulin-Like Growth Factor IMacrophagesMaleMiceRegenerative MedicineTissue EngineeringDecellularized Extracellular MatrixInsulin-Like Growth Factor I

Identifiers

PMID42805971
PMCPMC13620144

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.