Evidence map›Paper›PMID 42805940›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Novel genetic profile linked to cognitive decline in Hispanics/Latinos.

Yana Hrytsenko, Yogesh Purushotham, Zhirou Li, Carmen R Isasi, Wassim Tarraf, Alberto R Ramos, Martha L Daviglus, Humberto Parada, Brian W Spitzer, Mariko Isshiki and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Novel genetic profile linked to cognitive decline in Hispanics/Latinos.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yana HrytsenkoCardiovascular division, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-4683-8883
Yogesh PurushothamCardiovascular division, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Zhirou LiCardiovascular division, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Carmen R IsasiDepartment of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.
Wassim TarrafInstitute of Gerontology & Department of Healthcare Sciences, Wayne State University, Detroit, Michigan, USA.
Alberto R RamosDepartment of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Martha L DaviglusDepartment of Medicine, Institute for Minority Health Research, University of Illinois at Chicago, Chicago, Illinois, USA.
Humberto ParadaDivision of Epidemiology and Biostatistics, School of Public Health, San Diego State University, San Diego, California, USA.
Brian W SpitzerCardiovascular division, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Mariko IsshikiDepartments of Genetics, Albert Einstein College of Medicine, Bronx, New York, USA.
Srilakshmi M RajDepartments of Genetics, Albert Einstein College of Medicine, Bronx, New York, USA.
Charles DeCarliDepartment of Neurology, University of California Davis, Sacramento, California, USA.
Hector M GonzálezDepartment of Neurosciences, University of California San Diego, La Jolla, California, USA.
Myriam FornageBrown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Tamar SoferCardiovascular division, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

Funding

Study of Latinos-Investigation of Neurocognitive Aging-Alzheimer's diseaseR01AG075758 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Charles DeCarli, Hector M Gonzalez · 2022 to 2026
$21.7M
NIA NIH HHS R01 AG075758NIA NIH HHS R01AG075758
6 · The paper itself

Abstract

backgroundThe APOE ε4 allele has weaker association with ADRD outcomes in Hispanic/Latino populations compared to non-Hispanic White and East Asian populations.

methodsWe used whole-genome sequencing data from 13,025 Hispanic/Latino adults to infer population groups (clusters) from short DNA sequences at the APOE gene region. We estimated the associations between these clusters and mild cognitive impairment (MCI) and age-adjusted significant cognitive decline assessed via the Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA) study (n = 5334). We compared these associations to those of the conventional APOE alleles.

resultsWe identified three clusters of individuals. Relative to the largest Cluster 1, being in Cluster 3 had higher likelihood of having significant cognitive decline, with odds ratio (OR) = 1.47, 95% confidence interval (CI) [1.18, 1.84], p < 0.001. The association with having prevalent MCI at the SOL-INCA exam was not statistically significant, with OR = 1.33, 95% CI [0.97, 1.83], p = 0.08. Associations of the ε4 allele with these traits were not statistically significant. DISCUSSION: The new APOE profile has stronger risk association with age-adjusted significant cognitive decline in SOL-INCA Hispanics/Latinos compared to the ε4 allele.

Indexed as

Cognitive DysfunctionGenetic ProfileHispanic or LatinoAgedAllelesApolipoprotein E4Apolipoproteins EFemaleGenetic Predisposition to DiseaseHumansMaleWhole Genome SequencingApolipoprotein E4Apolipoproteins Eage‐adjusted cognitive declineAPOEAPOE heterogeneityapolipoprotein EHispanic/Latinoshort genomic sequencesunsupervised clusteringwhole‐genome sequencing

Identifiers

PMID42805940
PMCPMC13619723

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.