ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026
Tau-PET correlates of mild behavioral impairment in preclinical and prodromal Alzheimer's disease: A head-to-head comparison of Flortaucipir and MK6240.
Abstract readComparative Study
In one paragraph
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1citing papers in PubMed
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What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Tau-PET correlates of mild behavioral impairment in preclinical and prodromal Alzheimer's disease: A head-to-head comparison of Flortaucipir and MK6240.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
34 authors.
Isabella Bizzi *Translational Neuroimaging Laboratory, Montreal Neurological Institute, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC), McGill University, Montréal, Québec, Canada.ORCID https://orcid.org/0000-0002-3584-425X
Arthur C Macedo *Translational Neuroimaging Laboratory, Montreal Neurological Institute, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC), McGill University, Montréal, Québec, Canada.ORCID https://orcid.org/0000-0002-3957-0284
Lydia TrudelTranslational Neuroimaging Laboratory, Montreal Neurological Institute, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC), McGill University, Montréal, Québec, Canada.
Joseph TherriaultTranslational Neuroimaging Laboratory, Montreal Neurological Institute, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC), McGill University, Montréal, Québec, Canada.
Nesrine RahmouniTranslational Neuroimaging Laboratory, Montreal Neurological Institute, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC), McGill University, Montréal, Québec, Canada.
Firoza Z LussierDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Cécile TissotTranslational Neuroimaging Laboratory, Montreal Neurological Institute, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC), McGill University, Montréal, Québec, Canada.
Gleb BezginTranslational Neuroimaging Laboratory, Montreal Neurological Institute, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC), McGill University, Montréal, Québec, Canada.
Étienne AumontTranslational Neuroimaging Laboratory, Montreal Neurological Institute, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC), McGill University, Montréal, Québec, Canada.
Tevy ChanTranslational Neuroimaging Laboratory, Montreal Neurological Institute, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC), McGill University, Montréal, Québec, Canada.
Seyyed Ali HosseiniTranslational Neuroimaging Laboratory, Montreal Neurological Institute, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC), McGill University, Montréal, Québec, Canada.
Delphine Oliva-LopezTranslational Neuroimaging Laboratory, Montreal Neurological Institute, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC), McGill University, Montréal, Québec, Canada.
Marina Pereira GonçalvesTranslational Neuroimaging Laboratory, Montreal Neurological Institute, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC), McGill University, Montréal, Québec, Canada.
Guilherme PovalaDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Pamela C L FerreiraDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Bruna BellaverDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Livia AmaralDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Emma RuppertDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Marina Scop MedeirosDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Rayan MrouéDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Andréia RochaDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Kok Pin NgDepartment of Neurology, National Neuroscience Institute, Singapore, Singapore.
Eduardo R ZimmerBrain Institute of Rio Grande do Sul, PUCRS, Porto Alegre, Brazil.
Joseph MasdeuDepartment of Neurology, Houston Methodist Research Institute and Weill Cornell Medicine, Houston, Texas, USA.
Belen PascualDepartment of Neurology, Houston Methodist Research Institute and Weill Cornell Medicine, Houston, Texas, USA.
Val J LoweDepartment of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Hwamee OhDepartment of Psychiatry and Human Behavior, Brown University, Providence, Rhode Island, USA.
David N Soleimani-MeigooniLawrence Berkeley National Laboratory, Berkeley, California, USA.
Juan ForteaSant Pau Memory Unit, IR SANT PAU, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Zahinoor IsmailDepartment of Psychiatry, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Suzanne BakerLawrence Berkeley National Laboratory, Berkeley, California, USA.
Tharick A PascoalDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Pedro Rosa-NetoTranslational Neuroimaging Laboratory, Montreal Neurological Institute, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC), McGill University, Montréal, Québec, Canada.
HEAD Study
Funding
Longitudinal multicenter head-to-head harmonization of tau PET tracersR01AG073267 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BAKER, SUZANNE L, PASCOAL, THARICK · 2021 to 2025
$41.1MAlzheimer's AssociationAlzheimer Society of Canada #0000000158Canadian Consortium of Neurodegeneration and Aging MOP-11-51-31Centro de Investigación Biomédica en Red sobre Enfermedades NeurodegenerativasCentro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas Program 1Consortium canadien en neurodégénérescence associée au vieillissementCoordenação de Aperfeiçoamento de Pessoal de Nível Superior 88881.218211/2025-01Departament de Salut, Generalitat de CatalunyaDepartment de Salut de la Generalitat de Catalunya SLT006/17/00119Fondation Brain Canada 33397Fondation Brain Canada 34874Fondo de Investigaciones SanitarioFondo de Investigaciones Sanitario, Carlos III Health Institute INT21/00073Fondo de Investigaciones Sanitario, Carlos III Health Institute PI23/01786Fondo Europeo de Desarrollo Regional, Unión Europea, Una manera de hacer EuropaFoundation for the National Institutes of HealthFundación Tatiana Pérez de Guzmán el Bueno IIBSP-DOW-2020-151Horizon 2020 Framework ProgrammeInstituto de Salud Carlos IIINIA NIH HHS R01AG073267the Colin J Adair Charitable Foundationthe Fonds de Recherche du Québec - Santé 2020-VICO-279314the Fonds de Recherche du Québec - Santé 2024 VICO-356138Weston Brain Institute, Canadian Institutes of Health Research (CIHR) MOP-11-51-31Weston Brain Institute, Canadian Institutes of Health Research (CIHR) RFN 152985 159815 162303
Abstract
introductionWe compared the association between mild behavioral impairment (MBI) and first- versus second-generation tau-positron emission tomography (PET) tracers in preclinical and prodromal Alzheimer's disease (AD).
methodsWe assessed 110 individuals with head-to-head [
resultsFor both tracers, MBI severity was associated with tau-PET signal in all Braak regions and increased across PET-Braak stages. [ DISCUSSION: MBI in early AD is associated with tau-PET, with [
Indexed as
Alzheimer DiseaseCarbolinesCognitive DysfunctionPositron-Emission Tomographytau ProteinsAgedAged, 80 and overBrainFemaleHumansIsoquinolinesMaleProdromal SymptomsRadiopharmaceuticals7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indoleCarbolinesIsoquinolinesMK-6240Radiopharmaceuticalstau ProteinsAlzheimer DiseaseMild Behavioral ImpairmentNeuropsychiatric ManifestationsPositron‐Emission TomographyTau Pathology
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