ArticleJournal of neuroendocrinology2026
Prolactin receptor signalling contributes to the attenuation of stress-induced hyperthermia during pregnancy.
Article in Journal of neuroendocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
During pregnancy, thermoregulation is tightly controlled to protect the foetus from harmful elevated temperatures. Stress-induced hyperthermia is a component of the stress response that increases alertness to a perceived threat. Previous literature has shown that like other aspects of the stress response, stress-induced hyperthermia is attenuated in late pregnancy. We sought to investigate how stress-induced hyperthermia is attenuated in pregnancy of mice. The lactogenic hormones, prolactin and placental lactogen, have been previously shown to act through the prolactin receptor (Prlr) to keep maternal temperature in pregnancy low to ensure successful reproductive outcomes. We hypothesised that Prlr signalling in the brain would attenuate stress-induced hyperthermia during pregnancy. To investigate this, we specifically knocked out Prlr from glutamatergic (Vglut2) neurons in mice (Prlr
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