Evidence map›Paper›PMID 42805184›Full record

ArticleNeuron2026

A molecular and spinal circuit basis for the functional segregation of itch and pain.

Myung-Chul Noh, Kelly A Corrigan, Sean-Paul G Williams, Cedric Peirs, Michael J Leone, Daniel J Headrick, Mustafa Guvercin, Suhjin Lee, BaDoi N Phan, Xinyi Zhao and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Myung-Chul NohDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA; Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA, USA.
Kelly A CorriganDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA; Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA, USA.
Sean-Paul G WilliamsDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA.
Cedric PeirsDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA; Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA, USA; University Clermont-Auvergne, INSERM U1107: Neuro-Dol, Clermont Ferrand, France.
Michael J LeoneMedical Scientist Training Program, University of Pittsburgh, Pittsburgh, PA, USA; Computational Biology Department, School of Computer Science Carnegie Mellon University Pittsburgh, PA, USA.
Daniel J HeadrickDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA.
Mustafa GuvercinDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA.
Suhjin LeeDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA; Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA, USA.
BaDoi N PhanMedical Scientist Training Program, University of Pittsburgh, Pittsburgh, PA, USA; Computational Biology Department, School of Computer Science Carnegie Mellon University Pittsburgh, PA, USA.
Xinyi ZhaoDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA.
David A HenryDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA.
Deepika YeramosuComputational Biology Department, School of Computer Science Carnegie Mellon University Pittsburgh, PA, USA.
Sudhagar BabuDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA.
Ashley R BrownComputational Biology Department, School of Computer Science Carnegie Mellon University Pittsburgh, PA, USA.
Robert Van De WeerdComputational Biology Department, School of Computer Science Carnegie Mellon University Pittsburgh, PA, USA.
Richard P DumDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA.
Hansruedi MathysDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA.
Andreas R PfenningComputational Biology Department, School of Computer Science Carnegie Mellon University Pittsburgh, PA, USA.
Rebecca P SealDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA; Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: rpseal@pitt.edu.

Funding

Dorsal horn circuits for mechanical allodyniaR01NS107364 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SEAL, REBECCA P · 2019 to 2022
$2.1M
Investigation of Mechanical Allodynia Circuitry by the Nature of the InjuryR01NS139529 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REBECCA P SEAL · 2025 to 2026
$1.2M
Central Circuits for Mechanical PainR56NS104964 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SEAL, REBECCA P · 2018 to 2018
$543k
Cell-type specific molecular and functional analyses to target dorsal horn pain circuitry in mice and non-human primatesR56NS133364 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PFENNING, ANDREAS ROBERT, SEAL, REBECCA P · 2023 to 2023
$499k
NINDS NIH HHS R01 NS107364NINDS NIH HHS R01 NS139529NINDS NIH HHS R56 NS104964NINDS NIH HHS R56 NS133364
6 · The paper itself

Abstract

The dorsal horn is remarkably diverse, yet how this cellular complexity enables discrimination of sensory modalities remains a fundamental question. Neurons expressing the gastrin-releasing peptide receptor (Grpr

Indexed as

chronic paindorsal horngastrin-releasing peptide receptorgenomic enhancersitchmechanical allodynianeural circuitsneuropathic painpolyneuropathic paintranscriptomics

Identifiers

PMID42805184
PMCPMC13650988

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.