ArticlePoultry science2026
Protective effects of selenium-modified Viola philippica polysaccharide-loaded yeast microcapsules against Salmonella Typhimurium infection in chicks.
Article in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
This study aimed to investigate the protective effects of selenium-modified Viola philippica polysaccharide-loaded yeast microcapsules (SVPP@YM) against Salmonella Typhimurium (ST) infection in chicks. Encapsulation of SVPP by yeast microcapsules was confirmed via SEM, TEM, particle size analysis, zeta potential measurement, and FT-IR, with an encapsulation efficiency and loading capacity of 46.50 ± 2.80 % and 30.07 ± 1.71 %, respectively. In vitro, SVPP@YM showed no significant cytotoxicity toward HD11 cells at concentrations ranging from 3.125 to 12.5 μg/mL and exhibited higher cellular uptake efficiency than free SVPP. SVPP@YM effectively reduced NO, ROS, and MDA levels in LPS-stimulated HD11 cells, downregulated the expression of inflammatory mediators, and enhanced GSH-Px activity and SOD expression. In vivo, SVPP@YM alleviated ST-induced clinical symptoms, improved body weight and immune organ indices, preserved jejunal morphology, enhanced ZO-1 expression and tight junction-related gene expression, increased sIgA content, and reduced intestinal inflammatory and oxidative stress responses. In addition, SVPP@YM reshaped the gut microbiota composition by increasing microbial diversity, enriching beneficial bacteria, and reducing pathogenic taxa. Spearman correlation analysis further revealed that Escherichia-Shigella abundance was negatively correlated with parameters related to intestinal barrier function, mucosal immunity, and antioxidant capacity, but positively correlated with MDA, IL-1β, and TNF-α. Collectively, these findings indicate that SVPP@YM effectively protected chicks against ST-induced injury and may serve as a natural intervention strategy for ST infection in poultry.
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