Evidence map›Paper›PMID 42804568›Full record

ArticleCirculation2026

Modeling Heart Failure With Preserved Ejection Fraction Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Brian Yu, Lu Ren, Yu Liu, Chengyi Tu, Ana Kojic, Yuanyuan Dai, Ravichandra Venkateshappa, Mengcheng Shen, Shane R Zhao, Joseph C Wu

Abstract readLetter
In one paragraph

Article in Circulation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Brian Yu *Stanford Cardiovascular Institute, School of Medicine (B.Y., L.R., Y.L., C.T., A.K., Y.D., R.V., M.S., S.R.Z., J.C.W.), Stanford University, CA.ORCID 0000-0001-5250-1892
Lu Ren *Stanford Cardiovascular Institute, School of Medicine (B.Y., L.R., Y.L., C.T., A.K., Y.D., R.V., M.S., S.R.Z., J.C.W.), Stanford University, CA.ORCID 0000-0002-9731-8562
Yu LiuStanford Cardiovascular Institute, School of Medicine (B.Y., L.R., Y.L., C.T., A.K., Y.D., R.V., M.S., S.R.Z., J.C.W.), Stanford University, CA.
Chengyi TuStanford Cardiovascular Institute, School of Medicine (B.Y., L.R., Y.L., C.T., A.K., Y.D., R.V., M.S., S.R.Z., J.C.W.), Stanford University, CA.
Ana KojicStanford Cardiovascular Institute, School of Medicine (B.Y., L.R., Y.L., C.T., A.K., Y.D., R.V., M.S., S.R.Z., J.C.W.), Stanford University, CA.ORCID 0000-0002-1829-9990
Yuanyuan DaiStanford Cardiovascular Institute, School of Medicine (B.Y., L.R., Y.L., C.T., A.K., Y.D., R.V., M.S., S.R.Z., J.C.W.), Stanford University, CA.
Ravichandra VenkateshappaStanford Cardiovascular Institute, School of Medicine (B.Y., L.R., Y.L., C.T., A.K., Y.D., R.V., M.S., S.R.Z., J.C.W.), Stanford University, CA.ORCID 0000-0001-6510-380X
Mengcheng ShenStanford Cardiovascular Institute, School of Medicine (B.Y., L.R., Y.L., C.T., A.K., Y.D., R.V., M.S., S.R.Z., J.C.W.), Stanford University, CA.ORCID 0000-0001-7037-6159
Shane R ZhaoStanford Cardiovascular Institute, School of Medicine (B.Y., L.R., Y.L., C.T., A.K., Y.D., R.V., M.S., S.R.Z., J.C.W.), Stanford University, CA.ORCID 0000-0002-2137-5536
Joseph C WuStanford Cardiovascular Institute, School of Medicine (B.Y., L.R., Y.L., C.T., A.K., Y.D., R.V., M.S., S.R.Z., J.C.W.), Stanford University, CA.ORCID 0000-0002-6068-8041

Funding

Elucidating Mechanism of Cardiac Fibrosis with Cell Village of Pooled Human iPSCsR01HL130020 · NHLBI · STANFORD UNIVERSITY · PI Ronglih Liao, MARK MERCOLA · 2016 to 2026
$7.3M
Single Cell Sequencing of Human iPSC-CM Subtype Identity and FunctionR01HL145676 · NHLBI · STANFORD UNIVERSITY · PI MARK MERCOLA, Joseph C. Wu · 2019 to 2026
$5.1M
Assessing Effects of Microgravity on Cardiovascular Aging with AI and 3D OrganoidsUG3TR005845 · NCATS · STANFORD UNIVERSITY · PI BEHESHTI, AFSHIN, WU, JOSEPH C. · 2025 to 2025
$3.2M
Advancing Personalized Cardiac Organoids - Converging In Vitro, In Chemico, and In Silico ModelsUM1TR006031 · NCATS · STANFORD UNIVERSITY · PI Afshin Beheshti, Sarah C Heilshorn · 2026 to 2026
$3.1M
AI-driven Drug Discovery Targeting Cardiac Fibrosis in Aging HeartUG3AG097135 · NIA · STANFORD UNIVERSITY · PI SAYED, NAZISH, WU, JOSEPH C. · 2025 to 2025
$900k
Elucidating anti-angiogenic tyrosine kinase inhibitor-induced vascular dysfunctionR00HL166693 · NHLBI · WASHINGTON UNIVERSITY · PI Mengcheng Shen · 2025 to 2026
$498k
Tachycardia-induced Metabolic Remodeling Drives Cardiac DysfunctionK99HL164962 · NHLBI · STANFORD UNIVERSITY · PI TU, CHENGYI · 2023 to 2024
$303k
Mechanisms of Tyrosine Kinase Inhibitor-induced Sinoatrial Node DysfunctionK99HL179374 · NHLBI · STANFORD UNIVERSITY · PI Lu Ren · 2026 to 2026
$153k
NCATS NIH HHS UG3 TR005845NCATS NIH HHS UM1 TR006031NHLBI NIH HHS K99 HL164962NHLBI NIH HHS K99 HL179374NHLBI NIH HHS R00 HL166693NHLBI NIH HHS R01 HL130020NHLBI NIH HHS R01 HL145676NIA NIH HHS UG3 AG097135
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

diastoleheart failure, diastolicinduced pluripotent stem cellsmyocytes, cardiacorganoids

Identifiers

PMID42804568
PMCPMC13623075

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.