Evidence map›Paper›PMID 42804129›Full record

ArticleDrug delivery and translational research2026

Formulation development and in vitro evaluation of extemporaneous mucoadhesive in situ forming orals gels for localized therapy.

Radha Kulkarni, Rajesh V Lalla, Muhammad Faheem Hassan, Mu Ping Nieh, Saurabh Bhorkade, Diane J Burgess

Abstract read
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Article in Drug delivery and translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Radha KulkarniUniversity of Connecticut, School of Pharmacy, Storrs, CT, 06269, USA.
Rajesh V LallaUniversity of Connecticut, School of Dental Medicine, Farmington, CT, 06030, USA.
Muhammad Faheem HassanDepartment of Chemical and Biomolecular Engineering, University of Connecticut, Storrs, CT, 06269, USA.
Mu Ping NiehDepartment of Chemical and Biomolecular Engineering, University of Connecticut, Storrs, CT, 06269, USA.
Saurabh BhorkadeUniversity of Connecticut, School of Pharmacy, Storrs, CT, 06269, USA.
Diane J BurgessUniversity of Connecticut, School of Pharmacy, Storrs, CT, 06269, USA. d.burgess@uconn.edu.

Funding

DOE Office of Biological and Environmental Research KP1605010Institutes of Health, National Institute of General Medical Sciences (NIGMS) P30GM133893National Institutes of Health, National Institute of General Medical Sciences (NIGMS) through a P30 Grant P30GM133893National Science Foundation DMR-2420040
6 · The paper itself

Abstract

Oral mucositis is a debilitating complication of head and neck cancer therapy, characterized by ulceration and moderate to severe pain, often leading to treatment de-escalation, malnutrition, and reduced quality of life. Bupivacaine-loaded thermosensitive mucoadhesive in situ gels have previously demonstrated prolonged oral residence and superior localized analgesia. The goal of this study is to develop a systematic and scalable formulation development approach to prepare hospital-compoundable mucoadhesive in situ forming oral gels using a pre-approved bupivacaine HCl injection. Sodium carboxymethyl cellulose (sodium CMC) was selected as the mucoadhesive polymer, while Pluronic

Indexed as

Liquid crystalline structureMucoadhesionOral mucositisPersonalized medicinePluronics®Rheology

Identifiers

PMID42804129

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.