Evidence map›Paper›PMID 42804097›Full record

ArticleBulletin of experimental biology and medicine2026

Functional Shift of NLRP3 Inflammasome Activity in Aged Macrophages.

A V Blagova, A Satish, A K Berdnikov, S V Novikova, N A Rozanova, V S Voronina, N A Kolotieva, Y K Komleva, A B Salmina

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Article in Bulletin of experimental biology and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

A V BlagovaRussian Center of Neurology and Neurosciences, Moscow, Russia. annablagova2000@mail.ru.
A SatishRussian Center of Neurology and Neurosciences, Moscow, Russia.
A K BerdnikovRussian Center of Neurology and Neurosciences, Moscow, Russia.
S V NovikovaRussian Center of Neurology and Neurosciences, Moscow, Russia.
N A RozanovaRussian Center of Neurology and Neurosciences, Moscow, Russia.
V S VoroninaRussian Center of Neurology and Neurosciences, Moscow, Russia.
N A KolotievaRussian Center of Neurology and Neurosciences, Moscow, Russia.
Y K KomlevaRussian Center of Neurology and Neurosciences, Moscow, Russia.
A B SalminaRussian Center of Neurology and Neurosciences, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study investigates the functional remodeling of the NLRP3 inflammasome in bone marrow-derived macrophages during aging. Upon LPS stimulation, no increase in proinflammatory cytokine secretion was detected; however, NLRP3 activation was accompanied by an increase in DNA fragmentation. Pharmacological inhibition of the inflammasome with MCC950 attenuated apoptosis while simultaneously increasing the proportion of senescent cells, indicating a shift from apoptosis toward senescence. These findings suggest a functional shift in NLRP3 activity during aging: rather than playing a predominantly proinflammatory role, it participates in the regulation of the balance between apoptosis, senescence, and cell survival. This highlights the need for a cautious approach to the therapeutic inhibition of NLRP3 in age-associated pathologies.

Indexed as

InflammasomesMacrophagesNLR Family, Pyrin Domain-Containing 3 ProteinAgingAnimalsApoptosisCellular SenescenceDNA FragmentationFuransHeterocyclic Compounds, 4 or More RingsIndenesInterleukin-1betaLipopolysaccharidesMiceSulfonamidesFuransHeterocyclic Compounds, 4 or More RingsIndenesInflammasomesInterleukin-1betaLipopolysaccharidesN-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamideNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseSulfonamidesaginginflammagingmacrophagesNLRP3 inflammasome

Identifiers

PMID42804097

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.